ArticleThe Biochemical journal1992
Molecular cloning and expression of a new rat liver cell-CAM105 isoform. Differential phosphorylation of isoforms.
Article in The Biochemical journal, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 61 citations in OpenAlex.
- The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity.PloS one · 2012Article
- The CEACAM1-L Ser503 residue is crucial for inhibition of colon cancer cell tumorigenicity.Oncogene · 2001Article
- The CEACAM1-L glycoprotein associates with the actin cytoskeleton and localizes to cell-cell contact through activation of Rho-like GTPases.Molecular biology of the cell · 2000Article
- C-CAM1 expression: differential effects on morphology, differentiation state and suppression of human PC-3 prostate carcinoma cells.Oncogene · 1999Article
- Extracellular nucleotide signaling in the inner ear.Molecular neurobiology · 1998Review
- Evidence for regulated dimerization of cell-cell adhesion molecule (C-CAM) in epithelial cells.The Biochemical journal · 1996Article
- Identification of a new isoform of cell-cell adhesion molecule 105 (C-CAM), C-CAM4: a secretory protein with only one Ig domain.The Biochemical journal · 1996Article
- Enhancement of sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens by the novel ecto-ATPase inhibitor ARL 67156.British journal of pharmacology · 1996Article
- Structure and function of C-CAM1: effects of the cytoplasmic domain on cell aggregation.The Biochemical journal · 1995Article
- Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.Journal of virology · 1995Article
- Autoradiography-based cytochemical detection of ecto-ATPase, ecto-ADPase, 5'-nucleotidase, and extracellular adenosine production, employing 141Ce3+ as a capturing agent.The Histochemical journal · 1995Article
- Tissue distribution of liver regulating protein. Evidence for a cell recognition signal common to liver, pancreas, gonads, and hemopoietic tissues.The American journal of pathology · 1994Article
- The cytoplasmic domain of C-CAM is required for C-CAM-mediated adhesion function: studies of a C-CAM transcript containing an unspliced intron.The Biochemical journal · 1993Article
- Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms.Gene · 1993Article
- PEST sequences in calmodulin-binding proteins.Molecular and cellular biochemistryReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
An hepatocyte cell-adhesion molecule (cell-CAM105) was recently shown to be identical with the liver plasma-membrane ecto-ATPase. This protein has structural features of the immunoglobulin superfamily and is homologous with carcinoembryonic antigen proteins. We have cloned a cDNA encoding a new form of the cell-CAM105 which is a variant of the previously isolated clone. In addition to having a shorter cytoplasmic domain, the new isoform also has substitutions clustered in the first 130 amino acids of the extracellular domain. Both of these isoforms are expressed on the surface of hepatocytes with the shorter variant being the predominant form. The previously isolated cell-CAM105 (long form) has more potential phosphorylation sites than does the new isoform (short form). Both isoforms are found to be phosphorylated after incubation with [32P]phosphate in vitro, with the long form being phosphorylated to a significantly higher extent. This observed differential phosphorylation could be one of the mechanisms for the regulation of isoform functions. Using antipeptide antibodies specific for the long form and antibodies that are reactive with both isoforms, we have shown that both isoforms are localized in the canalicular domain of hepatocytes. The sequence differences between these two isoforms suggest that they are probably derived from different genes rather than from alternative splicing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.