ArticleAnnals of surgery2006
The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly.
Article in Annals of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 80 citations in OpenAlex.
- Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.Annals of surgery · 2018Trial
- Glucose Control in Severely Burned Patients Using Metformin: An Interim Safety and Efficacy Analysis of a Phase II Randomized Controlled Trial.Annals of surgery · 2016Trial
- The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes.PloS one · 2012Trial
- Pathophysiologic response to severe burn injury.Annals of surgery · 2008Trial
- Application of beta-blockers in burn management.Proceedings (Baylor University. Medical Center) · 2022Article
- The impact of catecholamines on skeletal muscle following massive burns: Friend or foe?Burns : journal of the International Society for Burn Injuries · 2021Review
- Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury.Frontiers in cell and developmental biology · 2020Review
- Review
- The biochemical alterations underlying post-burn hypermetabolism.Biochimica et biophysica acta. Molecular basis of disease · 2017Review
- Common Medications Which Lead to Unintended Alterations in Weight Gain or Organ Lipotoxicity.Current gastroenterology reports · 2016Review
- Progress in burns research: a review of advances in burn pathophysiology.Annals of burns and fire disasters · 2015Article
- Endoplasmic reticulum stress in adipose tissue augments lipolysis.Journal of cellular and molecular medicine · 2015Article
- Burns in children: standard and new treatments.Lancet (London, England) · 2014Review
- Association of postburn fatty acids and triglycerides with clinical outcome in severely burned children.The Journal of clinical endocrinology and metabolism · 2013Article
- Is propranolol of benefit in pediatric burn patients?Advances in surgery · 2013Review
- Burns: an update on current pharmacotherapy.Expert opinion on pharmacotherapy · 2012Review
- What, how, and how much should patients with burns be fed?The Surgical clinics of North America · 2011Review
- Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?Current opinion in clinical nutrition and metabolic care · 2011Review
- The hypermetabolic response to burn injury and interventions to modify this response.Clinics in plastic surgery · 2009Review
- Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs.Journal of the American College of Surgeons · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe objective of this study was to test the hypothesis that hepatomegaly in burned children can be attenuated or reversed by blocking lipolysis and reducing free fatty acids delivered to the liver. SUMMARY BACKGROUND DATA: Accelerated lipolysis in severely burned children has been shown to play an important role in the accumulation of hepatic TGs. Severely burned children who survive 10 days or more after injury commonly have enlarged livers often twice or more normal size for their sex, age, and weight.
methodsNinety-eight children, 2 to 18 years of age, with burns covering more than 40% of their body surface and who received either propranolol (beta-adrenergic blockade) or placebo were studied. Liver weights were measured by ultrasonic scanning. Body composition changes were identified by dual-image x-ray absorptiometry and validated by whole-body potassium-40 scintillation counting. Discarded abdominal cutaneous adipose tissue was collected before and after propranolol or placebo for microarray analysis.
resultsIn 80% of severely burned children studied not receiving propranolol, liver sizes increased by 100% or more while 86% of burned children receiving propranolol showed a decrease or no change in liver size over the same period of time after injury. Gene expression patterns of adipose tissue after propranolol treatment showed that all of the identified genes related to lipid metabolism were down-regulated.
conclusionsData reported here support the hypothesis that beta-adrenergic blockade can reduce delivery of fatty acids to the liver and hepatic congestion commonly found in severely burned children by inhibiting lipolysis and reducing hepatic blood flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.