Trial reportAnnals of surgery2006
Efficacy of Nissen fundoplication versus medical therapy in the regression of low-grade dysplasia in patients with Barrett esophagus: a prospective study.
Trial report in Annals of surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- AGA Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia.Gastroenterology · 2024Guideline
- Fundoplication is superior to medical therapy for Barrett's esophagus disease regression and progression: a systematic review and meta-analysis.Surgical endoscopy · 2022Pooled it
- Surgical treatment of GERD: systematic review and meta-analysis.Surgical endoscopy · 2021Pooled it
- Guidelines for surgical treatment of gastroesophageal reflux disease.Surgical endoscopy · 2010Guideline
- Treatment for Barrett's oesophagus.The Cochrane database of systematic reviews · 2010Pooled it
- Esophageal Motor Disorders Are a Strong and Independant Associated Factor of Barrett's Esophagus.Journal of neurogastroenterology and motility · 2018Article
- Barrett's esophagus in 2016: From pathophysiology to treatment.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Antireflux surgery for dysplastic Barrett.World journal of surgery · 2015Review
- Surveillance for low-grade dysplastic Barrett's oesophagus: one size fits all?World journal of surgery · 2015Review
- Optimal treatment of laryngopharyngeal reflux disease.Therapeutic advances in chronic disease · 2013Article
- Review on novel concepts of columnar lined esophagus.Wiener klinische Wochenschrift · 2013Review
- Natural history of Barrett's esophagus.World journal of gastroenterology · 2012Review
- Long-term results of ablation with antireflux surgery for Barrett's esophagus: a clinical and molecular biologic study.Surgical endoscopy · 2012Article
- Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma.Journal of gastroenterology and hepatology · 2012Article
- Barrett's esophagus: a review of the literature.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Review
- Effect of medical and surgical treatment of Barrett's metaplasia.World journal of gastroenterology · 2010Review
- Reflux esophagitis, high-grade neoplasia, and early Barrett's carcinoma-what is the place of the Merendino procedure?Langenbeck's archives of surgery · 2009Review
- Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence.World journal of gastroenterology · 2008Article
- Impact of changing epidemiology of gastroesophageal reflux disease on its diagnosis and treatment.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Review
- Regression of low-grade noninvasive neoplasia in barrett's epithelium: should we lower our guard?Annals of surgery · 2007Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to compare the effect of medical and surgical treatment on the history of patients with Barrett esophagus (BE) and histologic evidence of low-grade dysplasia (LGD). SUMMARY BACKGROUND DATA: BE is a complication of severe gastroesophageal reflux. It is considered a major risk factor for esophageal adenocarcinoma, which may develop through stages from nondysplastic metaplasia to dysplasia (LGD and high-grade dysplasia). Presently, there are no recommended therapeutic guidelines for patients with LGD.
methodsBetween 1998 through 2003, 6592 patients underwent upper endoscopy; 327 of 6592 (5%) patients had BE, and 35 of 327 (10.7%) had LGD. Nineteen patients with LGD were treated with high-dose proton pump inhibitors, and 16 patients underwent laparoscopic Nissen fundoplication. Endoscopic and histologic follow-up was available in all patients after 18 months. We used multiple logistic regression to examine the effect of the 2 treatments on regression of LGD.
resultsLGD was predominant in men (male-to-female ratio: 1.7:1). Mean age was 58 +/- 13.5 years. Sixty percent of patients had no endoscopic evidence of esophagitis. A regression from LGD to BE was observed in 12 of 19 (63.2%) patients in the medical group and in 15 of 16 (93.8%) patients in the surgical group (statistically significant difference). Differences between the 2 groups were statistically significant (P = 0.03).
conclusionThe results of our study suggest that surgical treatment may be more effective than medical therapy to modify the natural history of LGD in patients with BE, perhaps because it not only controls acid but also biliopancreatic reflux into the esophagus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.