Evidence map›Paper›PMID 16371573›Full record

ArticleChemical senses2006

Pulse stimulation with odors or IBMX/forskolin potentiates responses in isolated olfactory neurons.

Wenling Zhang, Rona J Delay

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical senses, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Wenling Zhang104 Marsh Life Science Building, Department of Biology, University of Vermont, Burlington, VT 05405, USA.
Rona J Delay
University of Vermont · US

Funding

Proteomics Core for Neuroscience P20 RR16435P20RR016435 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2001 to 2010
$23.5M
Intracellular chloride regulation in olfactory neurons.R01DC006939 · NIDCD · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI DELAY, RONA J · 2004 to 2008
$1.8M
MODULATION OF OLFACTORY NEURONS BY GNRH AND DOPAMINER03DC003912 · NIDCD · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI DELAY, RONA J · 1998 to 2000
$52k
NCRR NIH HHS P20 RR016435NCRR NIH HHS P20 RR016435-010001NCRR NIH HHS P20 RR016435-020001NCRR NIH HHS P20 RR016435-02S10001NCRR NIH HHS P20 RR016435-040001NCRR NIH HHS P20 RR016435-055071NCRR NIH HHS P20RR16435NIDCD NIH HHS DC006939NIDCD NIH HHS R01 DC006939NIDCD NIH HHS R01 DC006939-01NIDCD NIH HHS R01 DC006939-02NIDCD NIH HHS R03DC03912
6 · The paper itself

Abstract

Many odor responses are mediated by the adenosine 3',5'-cyclic monophosphate (cAMP) pathway in which the cAMP-gated current is amplified by Ca2+-dependent Cl- current. In olfactory neurons, prolonged exposure to odors decreases the odor response and is an adaptive effect. Several studies suggest that odor adaptation is linked to elevated intracellular Ca2+. In the present study, using the perforated configuration of the patch clamp technique, we found that repetitive odor stimulation elicits a potentiation of the subsequent responses in olfactory neurons. This potentiation is mimicked by stimulating the cAMP pathway and does not appear to be related to phosphorylation of ion channels since protein kinase inhibitors could not block it. Our data suggest that local increases in [Ca2+]i via activation of the cAMP pathway mediate the pulse-elicited potentiation. In the first odor application, entry of Ca2+ through cyclic nucleotide-gated channels appears to be buffered. Repetitive stimulation allows local increases in [Ca2+]i, recruiting more Ca2+-dependent Cl- channels with each subsequent odor pulse.

Indexed as

1-Methyl-3-isobutylxanthineAnimalsCalciumCalcium ChannelsCells, CulturedCell SeparationChloride ChannelsChloridesColforsinDrug SynergismElectrophysiologyFemaleMaleModels, BiologicalNecturusOlfactory Receptor Neurons1-Methyl-3-isobutylxanthineCalciumCalcium ChannelsChloride ChannelsChloridesColforsinProtein Kinase Inhibitors

Identifiers

PMID16371573
PMCPMC1440721
OpenAlexW2108205958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.