ArticleNeurotoxicity research2005
Development of neurological reflexes and motor coordination in rats neonatally treated with monosodium glutamate.
Article in Neurotoxicity research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Quantitative neurotoxic effects of heavy metals and glutamate in mouse hippocampal neuronal cells.Environmental analysis, health and toxicology · 2025Article
- Effects of Chicory (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Neuromotor Development in theBrain sciences · 2022Article
- Identification of regulated proteins by resveratrol in glutamate-induced cortical injury of newborn rats.The Journal of veterinary medical science · 2021Article
- The Behavior and Postnatal Development in Infant and Juvenile Rats After Ultrasound-Induced Chronic Prenatal Stress.Frontiers in physiology · 2021Article
- Intranasal Administration of Mesenchymal Stem Cell Secretome Reduces Hippocampal Oxidative Stress, Neuroinflammation and Cell Death, Improving the Behavioral Outcome Following Perinatal Asphyxia.International journal of molecular sciences · 2020Article
- Butanol Extract of Tinospora cordifolia Ameliorates Cognitive Deficits Associated with Glutamate-Induced Excitotoxicity: A Mechanistic Study Using Hippocampal Neurons.Neuromolecular medicine · 2020Article
- Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life.PloS one · 2019Article
- Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration.Oxidative medicine and cellular longevity · 2017Article
- Environmental enrichment decreases asphyxia-induced neurobehavioral developmental delay in neonatal rats.International journal of molecular sciences · 2013Article
- Exposure to enriched environment decreases neurobehavioral deficits induced by neonatal glutamate toxicity.International journal of molecular sciences · 2013Article
- Cerebellar brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 expression in male and female rats is differentially affected by hypergravity exposure during discrete developmental periods.Cerebellum (London, England) · 2009Article
- Changes in open-field activity and novelty-seeking behavior in periadolescent rats neonatally treated with monosodium glutamate.Neurotoxicity research · 2007Article
- Neurotoxins and neurotoxicity mechanisms. An overview.Neurotoxicity research · 2006Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monosodium glutamate (MSG) treatment of neonatal rats causes neuronal degeneration in various brain areas and leads to several neurochemical, endocrinological and behavioral alterations. However, relatively little is known about the development of neurological reflexes and motor coordination of these animals. Therefore, the aim of the present study was to examine the neurobehavioral development of newborn rats treated with MSG. Rats received MSG at postnatal days 1, 3, 5, 7, and 9. Appearance of neural reflexes and reflex performance as well as motor coordination were examined for 5 weeks after birth. The efficacy of MSG treatment was confirmed by histological examination of the arcuate nucleus. We found that MSG treatment delayed the appearance of forelimb placing, forelimb grasp and righting reflexes, besides the retarded somatic development. The treated pups performed surface righting in significantly longer times. Also, worse performance was observed in the foot-fault and rota-rod tests. However, MSG-treated rats reached control levels by the end of the fifth postnatal week. These results show that MSG treatment does not cause permanent alterations in the neurobehavioral development, only delays the appearance of some reflexes and leads to temporary changes in reflex performance and motor coordination signs.
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