ArticleJournal of bone and mineral metabolism2006
Bone mineral density and turnover in patients with acromegaly in relation to sex, disease activity, and gonadal function.
Article in Journal of bone and mineral metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Determinants of skeletal fragility in acromegaly: a systematic review and meta-analysis.Pituitary · 2022Pooled it
- Hyperostosis frontalis interna and association of disease control with frontal bone thickness in acromegaly.BMC endocrine disorders · 2025Article
- Neuroendocrinology of bone.Pituitary · 2024Review
- Acromegaly and the long-term fracture risk of the vertebra and hip: a national cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Trabecular Bone Score as a Reliable Measure of Lumbar Spine Bone Microarchitecture in Acromegalic Patients.Journal of clinical medicine · 2022Article
- Musculoskeletal Effects of Altered GH Action.Frontiers in physiology · 2022Review
- Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly.Frontiers in endocrinology · 2022Article
- Bone biochemical markers in acromegaly: An association with disease activity and gonadal status.Northern clinics of Istanbul · 2022Article
- Low sclerostin levels after long-term remission of acromegaly.Endocrine · 2022Article
- Trabecular bone score and bone mineral density in acromegalic osteopathy assessment: a cross-sectional study.Archives of osteoporosis · 2021Article
- Spine Bone Texture Assessed by Trabecular Bone Score in Active and Controlled Acromegaly: A Prospective Study.Journal of the Endocrine Society · 2021Article
- Biochemical bone turnover markers in hormonal disorders in adults: a narrative review.Journal of endocrinological investigation · 2020Review
- Entropy and uniformity as additional parameters to optimize the effectiveness of bone CT in the evaluation of acromegalic patients.Endocrine · 2020Article
- Exon 3-deleted growth hormone receptor isoform is not related to worse bone mineral density or microarchitecture or to increased fracture risk in acromegaly.Journal of endocrinological investigation · 2020Article
- The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly.Zeitschrift fur Rheumatologie · 2017Article
- Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.Endocrinology · 2017Article
- Trabecular bone score as a skeletal fragility index in acromegaly patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.Endocrinology · 2015Article
- Pituitary disorders and osteoporosis.International journal of endocrinology · 2015Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acromegaly is a rare disease caused by growth hormone (GH) hypersecretion. GH and insulin-like growth factor-I (IGF-I) exert anabolic activity in bones. Nevertheless, bone mineral density (BMD) loss is not uncommon in patients with acromegaly. It is assumed to be due to hypogonadism associated with the acromegaly. The aim of the study was to examine BMD at various skeletal sites and bone turnover and to assess the influence of impaired gonadal function and disease activity on BMD and turnover changes in acromegaly. A total of 62 patients were studied (40 women, 22 men). Among the women, 22 had active disease and 18 were cured; 16 women had normal gonadal function, and 24 were hypogonadal. Altogether, 12 men presented with active acromegaly, and 10 were cured; normal gonadal function was found in 10 men, and hypogonadism was diagnosed in 12 men. Controls were 30 healthy subjects. Densitometry using dual-energy X-ray absorptiometry of the lumbar spine, proximal femur, forearm, and total body was carried out. Bone turnover was studied based on serum osteocalcin, C-terminal collagen type 1 crosslinks, and bone alkaline phosphatase concentration. A disadvantageous effect of acromegaly on bone density was associated with hypogonadism in the distal radius (in women), the proximal femur (in men), and the total body (both sexes). An anabolic effect of GH during active acromegaly was present in the proximal femur only in men. We confirmed increased bone turnover in the presence of acromegaly, and these changes were similar regarding the activity of the disease and the gonadal status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.