ArticleJournal of bone and mineral metabolism2006
Relations between interleukin-1, its receptor antagonist gene polymorphism, and bone mineral density in postmenopausal Korean women.
Article in Journal of bone and mineral metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Beyond the Surface: Uncovering Secondary Causes of Osteoporosis for Optimal Management.Biomedicines · 2024Review
- "Inflammaging" and bone in the OsteoLaus cohort.Immunity & ageing : I & A · 2020Article
- Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Olive oil exhibits osteoprotection in ovariectomized rats without estrogenic effects.Experimental and therapeutic medicine · 2016Article
- Polymorphisms of the human IL-1 receptor antagonist gene and forearm bone mineral density in postmenopausal women.Indian journal of endocrinology and metabolism · 2012Article
- Systemic bone effects of biologic therapies in rheumatoid arthritis and ankylosing spondylitis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Review
- Vitamin D and bone health: potential mechanisms.Nutrients · 2010Review
- Current evidence for a modulation of low back pain by human genetic variants.Journal of cellular and molecular medicine · 2009Review
- Osteoporosis in celiac disease and in endocrine and reproductive disorders.World journal of gastroenterology · 2008Review
- MULTIDIRECTIONAL ASSESSMENT OF BONE STRUCTURE INCLUDING RADIOISOTOPIC ANALYSIS IN PERIMENOPAUSAL WOMEN.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Association of interleukin-1 beta (-511C/T) polymorphisms with osteoporosis in postmenopausal women.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the relation between polymorphisms in the interleukin-1(IL-1) and IL-1 receptor antagonist (IL-1ra) gene, and bone mineral density (BMD) in postmenopausal Korean women. The IL-1alpha C(-889)T polymorphism, and IL-1beta C(-511)T polymorphism were examined by restriction fragment length polymorphism, and 86-bp variable number tandem repeat polymorphism in the IL-1ra gene was analyzed by the polymerase chain reaction and electrophoresis in 202 postmenopausal Korean women. Serum osteocalcin, and C-telopeptide of type I collagen were measured using a radioimmunoassay and enzyme-linked immunosorbent assay, respectively. BMD at the lumbar spine and proximal femur was measured by dual-energy X-ray absorptiometer. No significant differences in BMD or in serum bone markers levels were noted across the IL-1alpha or IL-1beta genotype. There were no significant differences in the distribution of IL-1alpha or IL-1beta genotype according to the status of bone mass. BMD in women carrying the A2 allele of the IL-1ra gene was significantly lower than those without this allele, and the A2 allele was more frequent in osteoporotic women than in normal women. These data suggest that IL-1ra gene VNTR polymorphism is a genetic factor that may affect BMD in Korean women.
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