ArticleHuman genetics2006
Extreme skewing of X chromosome inactivation in mothers of homosexual men.
Article in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 73 citations in OpenAlex.
- Biodevelopmental Correlates of Sexual Orientation in Men: Evidence from a Polish Sample.Archives of sexual behavior · 2025Article
- A broader cultural view is necessary to study the evolution of sexual orientation.Nature ecology & evolution · 2024Article
- The Biodevelopment of Sexual Orientation: Beyond the Known Horizon.Archives of sexual behavior · 2023Article
- Effect of adverse childhood experiences and DNA methylation on male sexual orientation.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021Article
- Sexual partner preference in animals and humans.Neuroscience and biobehavioral reviews · 2020Review
- Associations of Bisexuality and Homosexuality with Handedness and Footedness: A Latent Variable Analysis Approach.Archives of sexual behavior · 2019Article
- Intragenomic Conflict and Immune Tolerance: Do Selfish X-Linked Alleles Drive Skewed X Chromosome Inactivation?Genome biology and evolution · 2018Article
- Genome-Wide Association Study of Male Sexual Orientation.Scientific reports · 2017Article
- Human homosexuality: a paradigmatic arena for sexually antagonistic selection?Cold Spring Harbor perspectives in biology · 2015Review
- Instability in X chromosome inactivation patterns in AMD: a new risk factor?Medical hypothesis, discovery & innovation ophthalmology journal · 2013Review
- Article
- The genetics of sex differences in brain and behavior.Frontiers in neuroendocrinology · 2011Review
- Extremely skewed X-chromosome inactivation is increased in pre-eclampsia.Human genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human sexual preference is a sexually dimorphic trait with a substantial genetic component. Linkage of male sexual orientation to markers on the X chromosome has been reported in some families. Here, we measured X chromosome inactivation ratios in 97 mothers of homosexual men and 103 age-matched control women without gay sons. The number of women with extreme skewing of X-inactivation was significantly higher in mothers of gay men (13/97=13%) compared to controls (4/103=4%) and increased in mothers with two or more gay sons (10/44=23%). Our findings support a role for the X chromosome in regulating sexual orientation in a subgroup of gay men.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.