ArticleOncogene2006
Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis.Biomedicines · 2022Article
- Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease.Frontiers in neuroscience · 2021Review
- Why Do the Cosmic Rays Induce Aging?Frontiers in physiology · 2020Review
- On the epigenetic role of guanosine oxidation.Redox biology · 2020Review
- Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis.Circulation · 2018Article
- Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.Redox biology · 2018Article
- Restoration of Cognitive Performance in Mice Carrying a Deficient Allele of 8-Oxoguanine DNA Glycosylase by X-ray Irradiation.Neurotoxicity research · 2018Article
- Article
- No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.Scientific reports · 2017Article
- Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).ACS chemical biology · 2015Article
- Inflammation-induced cell proliferation potentiates DNA damage-induced mutations in vivo.PLoS genetics · 2015Article
- Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence.Nucleic acids research · 2013Article
- Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2011Article
- 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress.Free radical biology & medicine · 2010Article
- Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions.Neurobiology of aging · 2010Article
- Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.PLoS genetics · 2009Article
- DNA repair modulates the vulnerability of the developing brain to alkylating agents.DNA repair · 2009Article
- Oxoguanine glycosylase 1 protects against methamphetamine-enhanced fetal brain oxidative DNA damage and neurodevelopmental deficits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains.DNA repair · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OGG1 (8-oxoguanine DNA glycosylase-1) is one of the main DNA glycosylases present in mammalian cells. The enzyme removes 7,8-dihydro-8-oxoguanine (8-oxoG) lesions, believed to be the most important oxidized lesions due to their relatively high incidence and their miscoding properties. This study shows that in prenatal mice brains the repair capacity for 8-oxoG is 5-10-fold higher than in adult mice brains. Western blot analysis and repair activity in extracts from Ogg1(-/-) mice revealed that OGG1 was responsible for the efficient 8-oxoG removal from prenatal mice. To investigate how OGG1 protects against oxidative stress-induced mutagenesis, pregnant Big Blue/wild-type and Big Blue/Ogg1(-/-) mice were exposed to nontoxic doses of gamma radiation. A 2.5-fold increase in the mutation frequency in Ogg1(-/-) mouse brains was obtained by exposure to 3.5 Gy at day 19 postfertilization. This was largely due to GC to TA transversions, believed to originate from 8-oxoG mispairing with A during replication. Furthermore, rapid cell divisions seemed to be required for fixation of mutations, as a similar dose of radiation did not increase the mutation frequency, or the frequency of GC to TA transversion, in the adult brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.