ArticleInfection and immunity2006
Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- The mannose receptor on sinusoidal lining cells mediates two-step bacterial clearance in the human spleen.Nature communications · 2026Article
- Article
- Effect of respiratory tract co-colonizers on initial attachment of Neisseria meningitidis.Archives of microbiology · 2023Article
- HrpA anchors meningococci to the dynein motor and affects the balance between apoptosis and pyroptosis.Journal of biomedical science · 2022Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats.Dental research journal · 2021Article
- Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils.Journal of proteome research · 2016Article
- Neisseria gonorrhoeae survives within and modulates apoptosis and inflammatory cytokine production of human macrophages.Cellular microbiology · 2016Article
- OtopathogenicFrontiers in microbiology · 2016Article
- Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.Clinical and experimental immunology · 2013Review
- Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Clinical microbiology reviews · 2013Review
- Review: apoptotic mechanisms in bacterial infections of the central nervous system.Frontiers in immunology · 2012Article
- Article
- The use of aminoguanidine, a selective inducible nitric oxide synthase inhibitor, to evaluate the role of nitric oxide on periapical healing.Dental research journal · 2011Article
- Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.Nature immunology · 2010Article
- Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.Infection and immunity · 2010Article
- Nitric oxide/cGMP signalling induces Escherichia coli K1 receptor expression and modulates the permeability in human brain endothelial cell monolayers during invasion.Cellular microbiology · 2010Article
- Bacterial nitric oxide detoxification prevents host cell S-nitrosothiol formation: a novel mechanism of bacterial pathogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Biochemical and genomic analysis of the denitrification pathway within the genus Neisseria.Microbiology (Reading, England) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.