ArticleInfection and immunity2006
Invasion of the placenta during murine listeriosis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Fetal and neonatal demise in zoonotic diseases: pathology and pathogenesis.Infection and immunity · 2026Review
- Neutrophils at the Maternal-Fetal Interface: Agents of Protection or Destruction?American journal of reproductive immunology (New York, N.Y. : 1989) · 2025Review
- Crossing the Barrier: A Comparative Study ofCells · 2023Review
- Infection of the murine placenta by Listeria monocytogenes induces sex-specific responses in the fetal brain.Pediatric research · 2023Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Review
- Novel internalin P homologs inMicrobial genomics · 2022Article
- Animal and Human Tissue Models of Vertical Listeria monocytogenes Transmission and Implications for Other Pregnancy-Associated Infections.Infection and immunity · 2018Review
- Vertical Transmission ofPathogens (Basel, Switzerland) · 2018Review
- Comparative experimental infection of Listeria monocytogenes and Listeria ivanovii in bovine trophoblasts.PloS one · 2017Article
- Contribution of Endemic Listeriosis to Spontaneous Abortion and Stillbirth in a Large Outdoor-housed Colony of Rhesus Macaques (Macaca mulatta).Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Interferon γ-induced GTPase promotes invasion of Listeria monocytogenes into trophoblast giant cells.Scientific reports · 2015Article
- Perinatal Listeria monocytogenes susceptibility despite preconceptual priming and maintenance of pathogen-specific CD8(+) T cells during pregnancy.Cellular & molecular immunology · 2014Article
- From mice to women: the conundrum of immunity to infection during pregnancy.Journal of reproductive immunology · 2013Review
- Tissue barriers of the human placenta to infection with Toxoplasma gondii.Infection and immunity · 2012Article
- Pregnancy reduces the genetic resistance of C57BL/6 mice to Listeria monocytogenes infection by intragastric inoculation.Microbial pathogenesis · 2011Article
- Article
- EEVD motif of heat shock cognate protein 70 contributes to bacterial uptake by trophoblast giant cells.Journal of biomedical science · 2009Article
- ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes.Infection and immunity · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feto-placental infections due to Listeria monocytogenes represent a major threat during pregnancy, and the underlying mechanisms of placental invasion remain poorly understood. Here we used a murine model of listeriosis (pregnant mice, infected at day 14 of gestation) to investigate how this pathogen invades and grows within the placenta to ultimately infect the fetus. When L. monocytogenes is injected intravenously, the invasion of the placenta occurs early after the initial bacteremia, allowing the placental growth of the bacteria, which is an absolute requirement for vertical transmission to the fetus. Kinetically, bacteria first target the cells lining the central arterial canal of the placenta, which stain positively with cytokeratin, demonstrating their fetal trophoblast origin. Bacteria then disseminate rapidly to the other trophoblastic structures, like syncytiotrophoblast cells lining the villous core in the labyrinthine zone of placenta. Additionally, we found that an inflammatory reaction predominantly constituted of polymorphonuclear cells occurs in the villous placenta and participates in the control of infection. Altogether, our results suggest that the infection of murine placenta is dependent, at the early phase, on circulating bacteria and their interaction with endovascular trophoblastic cells. Subsequently, the bacteria spread to the other trophoblastic cells before crossing the placental barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.