ArticleInfection and immunity2006
Antigen discovery: a postgenomic approach to leprosy diagnosis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 75 citations in OpenAlex.
- Immunologically reactive M. leprae antigens with relevance to diagnosis and vaccine development.BMC infectious diseases · 2011Trial
- In search of biomarkers for leprosy by unraveling the host immune response to Mycobacterium leprae.Immunological reviews · 2021Review
- Insights intoProteomes · 2021Review
- Prospects for new leprosy diagnostic tools, a narrative review considering ELISA and PCR assays.Revista da Sociedade Brasileira de Medicina Tropical · 2020Review
- Decoding the similarities and differences among mycobacterial species.PLoS neglected tropical diseases · 2017Article
- Analysis of antigens of Mycobacterium leprae by interaction to sera IgG, IgM, and IgA response to improve diagnosis of leprosy.BioMed research international · 2014Review
- Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.Clinical and vaccine immunology : CVI · 2013Article
- Evaluation of various cytokines elicited during antigen-specific recall as potential risk indicators for the differential development of leprosy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Current approaches and future directions in the treatment of leprosy.Research and reports in tropical medicine · 2012Review
- Enoyl-coenzyme A hydratase and antigen 85B of Mycobacterium habana are specifically recognized by antibodies in sera from leprosy patients.Clinical and vaccine immunology : CVI · 2011Article
- Identification of antigens specific to non-tuberculous mycobacteria: the Mce family of proteins as a target of T cell immune responses.PloS one · 2011Article
- Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics.PLoS neglected tropical diseases · 2010Article
- High throughput sequencing and proteomics to identify immunogenic proteins of a new pathogen: the dirty genome approach.PloS one · 2009Article
- Defining mycobacteria: Shared and specific genome features for different lifestyles.Indian journal of microbiology · 2009Article
- From genome-based in silico predictions to ex vivo verification of leprosy diagnosis.Clinical and vaccine immunology : CVI · 2009Article
- Antigen-specific T-cell responses of leprosy patients.Clinical and vaccine immunology : CVI · 2008Article
- Immunological dominance of Trypanosoma cruzi tandem repeat proteins.Infection and immunity · 2008Article
- Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.Clinical and vaccine immunology : CVI · 2008Article
- Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts.Clinical and vaccine immunology : CVI · 2008Article
- Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex.Infection and immunity · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Leprosy is an infectious, neurodegenerative disease of humans caused by Mycobacterium leprae. Despite effective control programs, the incidence of leprosy remains stubbornly high, suggesting that transmission may be more common than expected. The rationale of this work was to use bioinformatics and comparative genomics to identify potentially antigenic proteins for diagnostic purposes. This approach defined three classes of proteins: those restricted to M. leprae (class I), those present in M. leprae with orthologues in other organisms besides mycobacteria (class II), and exported or surface-exposed proteins (class III). Twelve genes (two class I, four class II, and six class III proteins) were cloned in Escherichia coli, and their protein products were purified. Six of these proteins were detected in cell extracts of M. leprae by immunoblotting. The immunogenicity of each recombinant protein was then investigated in leprosy patients by measuring the reactivity of circulating antibody and gamma interferon (IFN-gamma) responses in T-cell restimulation assays. Several class II and class III proteins were recognized by circulating antibodies. Importantly, most class II proteins elicited IFN-gamma responses that were significantly stronger than those produced by previously identified antigens. Among them, two class II proteins, ML0308 and ML2498, showed marked humoral and cellular immunogenicity, therefore providing promising candidates for the diagnosis of both tuberculoid and lepromatous forms of leprosy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.