ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2006
Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Guideline
- Effectiveness and Prognostic Factors of Everolimus in Patients with Pancreatic Neuroendocrine Neoplasms.Internal medicine (Tokyo, Japan) · 2023Article
- Orchestrating Treatment Modalities in Metastatic Pancreatic Neuroendocrine Tumors-Need for a Conductor.Cancers · 2022Review
- Long-term outcome after resection and thermal hepatic ablation of pancreatic neuroendocrine tumour liver metastases.BJS open · 2021Article
- Younger Age Is Associated with Improved Survival in Patients Undergoing Liver Transplantation Alone for Metastatic Neuroendocrine Tumors.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Role of surgery in pancreatic neuroendocrine tumor.Gland surgery · 2018Review
- Resection of Liver Metastases: A Treatment Provides a Long-Term Survival Benefit for Patients with Advanced Pancreatic Neuroendocrine Tumors:Journal of oncology · 2018Review
- Chemotherapy in NETs: When and how.Reviews in endocrine & metabolic disorders · 2017Review
- Report of one case: surgical treatment for neuroendocrine tumors.Translational gastroenterology and hepatology · 2016Article
- Rectal neuroendocrine neoplasms: a case report.Translational gastroenterology and hepatology · 2016Article
- Palliative resection of the primary tumor in 442 metastasized neuroendocrine tumors of the pancreas: a population-based, propensity score-matched survival analysis.Langenbeck's archives of surgery · 2015Article
- Distal pancreatic resection for neuroendocrine tumors: is laparoscopic really better than open?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2015Article
- Surgical resection improves the outcome of the patients with neuroendocrine tumor liver metastases: large data from Asia.Medicine · 2015Article
- A Single Centre Analysis of Clinical Characteristics and Treatment of Endocrine Pancreatic Tumours.International journal of surgical oncology · 2015Article
- Tumor-associated macrophages are a useful biomarker to predict recurrence after surgical resection of nonfunctional pancreatic neuroendocrine tumors.Annals of surgery · 2014Article
- Laparoscopic resection of pancreatic neuroendocrine tumors.World journal of gastroenterology · 2014Review
- Emerging approaches in the management of patients with neuroendocrine liver metastasis: role of liver-directed and systemic therapies.Journal of the American College of Surgeons · 2013Review
- Clinical pathways for pancreatic neuroendocrine tumors.Journal of gastrointestinal cancer · 2012Review
- Survival impact of malignant pancreatic neuroendocrine and islet cell neoplasm phenotypes.Journal of surgical oncology · 2012Article
- [Surgery for neuroendocrine tumors of the gastroenteropancreatic system (GEP-NET)].Der Internist · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Well-differentiated islet cell tumors can be associated with aggressive biology, resulting in early metastases to the liver. This study was carried out to determine whether survival for patients with malignant islet cell tumors and synchronous liver metastases is affected by complete surgical resection. Thirty-one patients with synchronous liver metastases from islet cell cancer underwent surgical exploration with the intent for complete tumor resection, and all patients underwent resection of the pancreatic primary. The patients were divided into two groups, those with resectable versus unresectable liver metastases. Twenty-six of 31 (84%) patients underwent complete resection of both the primary tumor and all liver metastases, and 5 (16%) patients underwent only complete resection of the pancreatic primary without liver resection. To extirpate the primary tumor, a pancreaticoduodenectomy was performed in 11 of the 26 (42%) completely resected patients and in 4 of the 5 (80%) incompletely resected patients, P = NS. The remainder of the patients underwent distal pancreatectomy. There were no statistical differences in primary tumor size, lymph node metastases, or adjuvant treatments between patients with resected and unresected liver metastases. The median overall survival for the completely resected group was 78 months, longer than the 17 months for the group with unresectable liver metastases (P = 0.06). Complete tumor resection (or the tumor biology that allows such complete resection) affords a survival advantage to patients with metastatic islet cell tumors of the pancreas. Patterns of liver metastases from islet cell tumors, specifically multiple bilobar metastases that are not amenable to resection and/or ablation, predict a poor outcome despite resection of the primary pancreatic tumor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.