ReviewCurrent opinion in structural biology2006
DNA arms do the legwork to ensure the directionality of lambda site-specific recombination.
Review in Current opinion in structural biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Structural basis for control of integrative and conjugative element excision and transfer by the oligomeric winged helix-turn-helix protein RdfS.Nucleic acids research · 2025Article
- Landscape of mobile genetic elements and their antibiotic resistance cargo in prokaryotic genomes.Nucleic acids research · 2022Article
- Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes.Molecular systems biology · 2021Article
- Molecular Cloning Designer Simulator (MCDS): All-in-one molecular cloning and genetic engineering design, simulation and management software for complex synthetic biology and metabolic engineering projects.Metabolic engineering communications · 2016Article
- Real-time single-molecule tethered particle motion analysis reveals mechanistic similarities and contrasts of Flp site-specific recombinase with Cre and λ Int.Nucleic acids research · 2013Article
- A new large-DNA-fragment delivery system based on integrase activity from an integrative and conjugative element.Applied and environmental microbiology · 2013Article
- A single copy integration vector that integrates at an engineered site on the Staphylococcus aureus chromosome.BMC research notes · 2012Article
- Arm site independence of coliphage HK022 integrase in human cells.Molecular genetics and genomics : MGG · 2011Article
- The CTCF insulator protein forms an unusual DNA structure.BMC molecular biology · 2010Article
- Topoisomerases and site-specific recombinases: similarities in structure and mechanism.Critical reviews in biochemistry and molecular biology · 2010Review
- CTnDOT integrase interactions with attachment site DNA and control of directionality of the recombination reaction.Journal of bacteriology · 2010Article
- Control of directionality in the DNA strand-exchange reaction catalysed by the tyrosine recombinase TnpI.Nucleic acids research · 2010Article
- Selection of bacteriophage lambda integrases with altered recombination specificity by in vitro compartmentalization.Nucleic acids research · 2010Article
- Mechanical constraints on Hin subunit rotation imposed by the Fis/enhancer system and DNA supercoiling during site-specific recombination.Molecular cell · 2009Article
- Crystallization and structure determination of the core-binding domain of bacteriophage lambda integrase.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
- A biotin interference assay highlights two different asymmetric interaction profiles for lambda integrase arm-type binding sites in integrative versus excisive recombination.The Journal of biological chemistry · 2008Article
- Spermidine biases the resolution of Holliday junctions by phage lambda integrase.Nucleic acids research · 2007Article
- Sequences in attB that affect the ability of phiC31 integrase to synapse and to activate DNA cleavage.Nucleic acids research · 2007Article
- DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12.Journal of bacteriology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The integrase protein of bacteriophage lambda (Int) catalyzes site-specific recombination between lambda phage and Escherichia coli genomes. Int is a tyrosine recombinase that binds to DNA core sites via a C-terminal catalytic domain and to a collection of arm DNA sites, distant from the site of recombination, via its N-terminal domain. The arm sites, in conjunction with accessory DNA-bending proteins, provide a means of regulating the efficiency and directionality of Int-catalyzed recombination. Recent crystal structures of lambda Int tetramers bound to synaptic and Holliday junction intermediates, together with new biochemical data, suggest a mechanism for the allosteric control of the recombination reaction through arm DNA binding interactions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.