ArticleRetrovirology2005
Involvement of claudin-7 in HIV infection of CD4(-) cells.
Article in Retrovirology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus.Science China. Life sciences · 2025Article
- A CRISPR-Cas9-mediated F0 screen to identify pro-regenerative genes in the zebrafish retinal pigment epithelium.Scientific reports · 2023Article
- Porcine Reproductive and Respiratory Syndrome Virus Structural Protein GP3 Regulates Claudin 4 To Facilitate the Early Stages of Infection.Journal of virology · 2020Article
- Claudin-7 modulates cell-matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells.Oncology letters · 2019Article
- Non-canonical functions of claudin proteins: Beyond the regulation of cell-cell adhesions.Tissue barriers · 2017Review
- Claudins in viral infection: from entry to spread.Pflugers Archiv : European journal of physiology · 2017Review
- The role of epithelial tight junctions involved in pathogen infections.Molecular biology reports · 2014Review
- Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins.PloS one · 2012Article
- X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women.American journal of human genetics · 2009Article
- Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry.Human heredity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundHuman immunodeficiency virus (HIV) infection of CD4(-) cells has been demonstrated, and this may be an important mechanism for HIV transmission.
resultsWe demonstrated that a membrane protein, claudin-7 (CLDN-7), is involved in HIV infection of CD4(-) cells. A significant increase in HIV susceptibility (2- to 100-fold) was demonstrated when CLDN-7 was transfected into a CD4(-) cell line, 293T. In addition, antibodies against CLDN-7 significantly decreased HIV infection of CD4(-) cells. Furthermore, HIV virions expressing CLDN-7 on their envelopes had a much higher infectivity for 293T CD4(-) cells than the parental HIV with no CLDN-7. RT-PCR results demonstrated that CLDN-7 is expressed in both macrophages and stimulated peripheral blood leukocytes, suggesting that most HIV virions generated in infected individuals have CLDN-7 on their envelopes. We also found that CLDN-7 is highly expressed in urogenital and gastrointestinal tissues.
conclusionTogether these results suggest that CLDN-7 may play an important role in HIV infection of CD4(-) cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.