ArticleClinical and experimental immunology2006
The larynx as an immunological organ: immunological architecture in the pig as a large animal model.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Gut-larynx axis and its contribution to laryngeal immunity.mSystems · 2025Article
- Toll Like Receptors in the Larynx: Implications for Laryngeal Immunology.The Laryngoscope · 2025Article
- Impact of tobacco exposure on global deaths of digestive diseases: Findings from 1990-2021 and projected trends to 2042.Tobacco induced diseases · 2025Article
- Article
- Management of an Acute Airway Obstruction Due to Tracheal Carcinoma in a Patient With Severe Glottic Stenosis.Cureus · 2023Article
- Modulation of mouse laryngeal inflammatory and immune cell responses by low and high doses of mainstream cigarette smoke.Scientific reports · 2022Article
- A Method to Administer Agents to the Larynx in an Awake Large Animal.Journal of speech, language, and hearing research : JSLHR · 2017Article
- Laryngeal T regulatory cells in the setting of smoking and reflux.The Laryngoscope · 2017Article
- The human laryngeal microbiome: effects of cigarette smoke and reflux.Scientific reports · 2016Article
- Toward an Understanding of the Pathophysiology of Chronic Laryngitis.Perspectives of the ASHA special interest groups · 2016Article
- In vivo investigation of acidified pepsin exposure to porcine vocal fold epithelia.The Laryngoscope · 2016Article
- Utility of cell viability assays for use with ex vivo vocal fold epithelial tissue.The Laryngoscope · 2015Article
- Interspecies comparison of stellate cell-containing macula flavae and vitamin A storage in vocal fold mucosa.Journal of anatomy · 2014Article
- Laryngeal transplantation in minipigs: early immunological outcomes.Clinical and experimental immunology · 2012Article
- Cross-sample validation provides enhanced proteome coverage in rat vocal fold mucosa.PloS one · 2011Article
- Laryngeal transplantation in minipigs: vascular, myologic and functional outcomes.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Article
- Rearing environment affects development of the immune system in neonates.Clinical and experimental immunology · 2010Article
- Hypertonic challenge to porcine vocal folds: effects on epithelial barrier function.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2010Article
- At the crossroads: mucosal immunology of the larynx.Mucosal immunology · 2009Review
- The mucosal immune response to laryngopharyngeal reflux.American journal of respiratory and critical care medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The larynx is a mucosal organ positioned at the divergence of the respiratory and digestive tracts. It is exposed to a wide variety of environmental components, including foreign antigens, tobacco smoke, laryngopharyngeal reflux and pollutants. The mucosal immune system generates either active immune responses or tolerance, depending on the nature of the antigen and we hypothesize that the larynx is important organ for immunological decision-making in the airway. Because the pig is an ideal large animal model in which to explore laryngological research questions, such as those relating to laryngeal transplantation, we investigated the normal mucosal immunology of the porcine larynx. Pig larynges and tracheae were processed and prepared for bright-field microscopy and quantitative, multiple-colour immunofluorescence histology using pig-specific monoclonal antibodies. There was an abundance of immunologically active cells within the mucosa of the larynx and trachea of both the newborn and adult animal. Specifically, major histocompatibility complex class II (MHC class II+) cells, CD4+ and CD8+ cells were identified, although regional differences in numbers were apparent: specifically, the supraglottis contained fewer immunologically relevant cells than other sites sampled. There was a significant correlation between the numbers of MHC class II+ and CD4+ cells indicating co-ordinate regulation and therefore functional local interactions. The presence of such an immunological structure suggests that the larynx may have important functions in respiratory immunology and that it may trigger strong alloresponses after laryngeal transplantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.