ArticleThe European journal of neuroscience2005
Compartmentalization of calcium entry pathways in mouse rods.
Article in The European journal of neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Retinal TRP channels: Cell-type-specific regulators of retinal homeostasis and multimodal integration.Progress in retinal and eye research · 2023Review
- Aging Impairs Renal Autoregulation in Mice.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Mouse transient receptor potential channel type 6 selectively regulates agonist-induced platelet function.Biochemistry and biophysics reports · 2019Article
- The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases.Molecular vision · 2016Article
- A critical role for the transient receptor potential channel type 6 in human platelet activation.PloS one · 2015Article
- Light-driven calcium signals in mouse cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Calcium stores in vertebrate photoreceptors.Advances in experimental medicine and biology · 2012Review
- TRPC6: an underlying target for human glaucoma.International journal of ophthalmology · 2012Article
- The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Emerging roles of canonical TRP channels in neuronal function.Advances in experimental medicine and biology · 2011Review
- Vertebrate vision: TRP channels in the spotlight.Current biology : CB · 2010Article
- Inhibitory effect of somatostatin-14 on L-type voltage-gated calcium channels in cultured cone photoreceptors requires intracellular calcium.Journal of neurophysiology · 2009Article
- Kinetics of synaptic transmission at ribbon synapses of rods and cones.Molecular neurobiology · 2007Review
- Temporal coupling of cyclic AMP and Ca/calmodulin-stimulated adenylyl cyclase to the circadian clock in chick retinal photoreceptor cells.Journal of neurochemistry · 2006Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Photoreceptor metabolism, gene expression and synaptic transmission take place in a highly polarized structure consisting of the ellipsoid, subellipsoid, cell body and synaptic terminal regions. Although calcium, a key second messenger, regulates cellular functions throughout the photoreceptor, the molecular mechanisms underlying local region-specific action of Ca2+ in photoreceptors are poorly understood. I have investigated the compartmentalization of voltage-dependent and independent Ca2+ channels in mouse photoreceptors. Transient receptor potential channels isoform 6 (TRPC6), a putative store-operated Ca2+ channel, was selectively localized to the cell body of rods. By contrast, voltage-operated Ca2+ channels were expressed in the synaptic terminal and in the ellipsoid/subellipsoid regions. Likewise, Ca2+ store transporters and channels were strongly associated with the subellipsoid region. A moderate TRPC6 signal was observed in cell bodies of bipolar, amacrine and ganglion cells, but was absent from both plexiform layers. These results suggest that Ca2+ entry mechanisms in mammalian photoreceptors and bipolar cells are highly compartmentalized, consistent with local, region-specific activation of Ca2+-dependent processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.