ArticleThe Biochemical journal2006
Molecular and functional characterization of a novel gonadotropin-releasing-hormone receptor isolated from the common octopus (Octopus vulgaris).
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 120 citations in OpenAlex.
- Molecular Characterization and Signaling Mechanisms of a Corazonin-Type System in Octopus minor.Marine biotechnology (New York, N.Y.) · 2026Article
- Evaluation of the Effect of Adipokinetic Hormone/Corazonin-Related Peptide (ACP) on Ovarian Development in the Mud Crab,Animals : an open access journal from MDPI · 2024Article
- Brain compartmentalization based on transcriptome analyses and its gene expression in Octopus minor.Brain structure & function · 2023Article
- Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species.Scientific reports · 2021Article
- Invertebrate Gonadotropin-Releasing Hormone Receptor Signaling and Its Relevant Biological Actions.International journal of molecular sciences · 2020Review
- Molecular Identification, Characterization, and Expression Analysis of a Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Pacific Abalone,Molecules (Basel, Switzerland) · 2020Article
- Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Cephalopod Brains: An Overview of Current Knowledge to Facilitate Comparison With Vertebrates.Frontiers in physiology · 2018Review
- Invertebrate Gonadotropin-Releasing Hormone-Related Peptides and Their Receptors: An Update.Frontiers in endocrinology · 2017Review
- Functional Characterization of Paralogous Gonadotropin-Releasing Hormone-Type and Corazonin-Type Neuropeptides in an Echinoderm.Frontiers in endocrinology · 2017Article
- The Gastric Ganglion ofFrontiers in physiology · 2017Article
- Adipokinetic hormones and their G protein-coupled receptors emerged in Lophotrochozoa.Scientific reports · 2016Article
- Article
- In Vivo Administration of Scallop GnRH-Like Peptide Influences on Gonad Development in the Yesso Scallop, Patinopecten yessoensis.PloS one · 2015Article
- At the transition from invertebrates to vertebrates, a novel GnRH-like peptide emerges in amphioxus.Molecular biology and evolution · 2014Article
- Nervous control of reproduction in Octopus vulgaris: a new model.Invertebrate neuroscience : IN · 2013Review
- Cephalopod neurobiology: an introduction for biologists working in other model systems.Invertebrate neuroscience : IN · 2013Review
- Gonadotropin-releasing hormone and adipokinetic hormone signaling systems share a common evolutionary origin.Frontiers in endocrinology · 2011Article
- A gonadotropin-releasing hormone-like molecule modulates the activity of diverse central neurons in a gastropod mollusk, aplysia californica.Frontiers in endocrinology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GnRH (gonadotropin-releasing hormone) plays a pivotal role in the regulation of reproduction in vertebrates through interaction with a specific receptor. Previously, we isolated a GnRH homologue, oct-GnRH, from the common octopus (Octopus vulgaris). In the present study, we have identified a GnRH receptor (oct-GnRHR) specific for oct-GnRH from Octopus brain. Oct-GnRHR includes domains and motifs typical of vertebrate GnRH receptors. The intron-inserted positions are conserved between oct-GnRHR and the chordate GnRHR genes. The oct-GnRHR expressed in Xenopus (South African clawed frog) oocytes was responsive to oct-GnRH, but not to any other HPLC fractions of the Octopus brain extract. These results show that oct-GnRHR is an authentic receptor for oct-GnRH. Southern blotting of reverse-transcription PCR products revealed that the oct-GnRHR mRNA was widely distributed in the central and peripheral nervous systems and in several peripheral tissues. In situ hybridization showed that oct-GnRHR mRNA was expressed in some regions involved in autonomic functions, feeding, memory and movement. Oct-GnRH was shown to induce steroidogenesis of testosterone, progesterone and 17beta-oestradiol in Octopus ovary and testis, where oct-GnRHR was abundantly expressed. These results suggest that oct-GnRH, like its vertebrate counterparts, acts as a multifunctional neurotransmitter, neuromodulator and hormone-like factor, both in Octopus central nervous system and peripheral tissues, and that both structure and functions of the GnRH family are, at least partially, evolutionarily conserved between octopuses and chordates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.