ArticleVirchows Archiv : an international journal of pathology2006
Oncocytic modifications in rectal adenocarcinomas after radio and chemotherapy.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Morphological features and molecular markers in rectal cancer from 95 patients included in the European Organisation for Research and Treatment of Cancer 22921 trial: prognostic value and effects of preoperative radio (chemo) therapy.European journal of cancer (Oxford, England : 1990) · 2008Trial
- High mitochondrial content is associated with breast cancer aggressiveness.Molecular and clinical oncology · 2021Article
- Article
- Conventional Imaging and Sonoelastography Findings of Oncocytic Breast Carcinoma in a Man.European journal of breast health · 2020Article
- Mitochondria-centric bioenergetic characteristics in cancer stem-like cells.Archives of pharmacal research · 2019Review
- Pathologic assessment of gastrointestinal tract and pancreatic carcinoma after neoadjuvant therapy.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Review
- Synchronous and bilateral oncocytic carcinoma of the breast: A case report and review of the literature.Oncology letters · 2017Article
- High mitochondria content is associated with prostate cancer disease progression.Molecular cancer · 2013Article
- Gamma rays induce a p53-independent mitochondrial biogenesis that is counter-regulated by HIF1α.Cell death & disease · 2013Article
- Oncocytic mania: a review of oncocytic lesions throughout the body.Journal of endocrinological investigation · 2011Review
- Squamous cell carcinoma of rectum presenting in a man: a case report.Journal of medical case reports · 2010Article
- Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23 fractions, were studied. All patients underwent biopsy before RCT. Surgery was performed within 6 weeks after RCT. In all cases oncocytic modifications were searched for on hematoxylin and eosin (H&E) and at immunohistochemistry using an antimitochondrial antibody. In addition, in two cases, both pre- and post-RCT tissues were examined at electron microscopy. All tumors were adenocarcinomas. In pre-RCT biopsies, oncocytic changes were difficult to find on H&E, while the antimitochondrial antibody strongly stained numerous neoplastic cells (mean 48.4%). In post-RCT surgical specimens, oncocytic changes were detected in 24 out of 28 cases on H&E and the antimitochondrial antibody stained most of the residual neoplastic cells (mean 76.7%). Ultrastructural examination revealed large and bizarre mitochondria inside tumor cells both in pre- and post-RCT tissues. In conclusion, the present data suggest that rectal adenocarcinomas are "mitochondrion-rich" tumors. After preoperative RCT, residual neoplastic cells acquire a definite oncocytic phenotype.
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