ArticleJournal of immunology (Baltimore, Md. : 1950)2006
Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases.
Article in Journal of immunology (Baltimore, Md. : 1950), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Novel somatic single nucleotide variants within the RNA binding protein hnRNP A1 in multiple sclerosis patients.F1000Research · 2014Article
- Clearance of Apoptotic Bodies, NETs, and Biofilm DNA: Implications for Autoimmunity.Frontiers in immunology · 2014Review
- 9G4+ autoantibodies are an important source of apoptotic cell reactivity associated with high levels of disease activity in systemic lupus erythematosus.Arthritis and rheumatism · 2013Article
- Biology of the TAM receptors.Cold Spring Harbor perspectives in biology · 2013Review
- A MERry response after myocardial infarction.Circulation research · 2013Article
- Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity.Seminars in immunopathology · 2013Review
- Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death.PloS one · 2013Article
- Antibody transfection into neurons as a tool to study disease pathogenesis.Journal of visualized experiments : JoVE · 2012Article
- Glucocorticoids relieve collectin-driven suppression of apoptotic cell uptake in murine alveolar macrophages through downregulation of SIRPα.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs.Molecular immunology · 2007Article
- Apoptotic cell death and lupus.Springer seminars in immunopathology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Deficiencies in clearance of apoptotic cells predispose to the development of autoimmune disease. This is evident in mice lacking the receptor tyrosine kinases Tyro3, Axl, and Mer. Deficient mice exhibit an increased abundance of apoptotic cells in tissues and manifest diverse autoimmune conditions. To test these mice for the presence of autoantibodies to apoptotic cells, we generated spontaneous splenic B cell hybridomas and used a novel microscopy screen to detect Ab binding to apoptotic Jurkat cells. From hybridomas secreting IgG Abs reactive with apoptotic cells, we selected one that recreated the major serum specificity for apoptotic cells. The Ab LHC7.15 bound to an Ag that is differentially distributed between the nucleus and the cytoplasm in live and apoptotic cells. In late apoptotic cells, the Ag coalesces into aggregates that bleb from the cell surface. Immunopurification of the Ag, followed by mass spectrometry, identified a protein of 69 kDa whose partial sequence matched heterogeneous nuclear ribonucleoprotein P2. This multifunctional protein binds DNA, RNA, and several known ribonucleoprotein autoantigens. Our observations indicate that a ribonucleoprotein complex, formed and translocated to the cell surface in apoptosis, represents a potent stimulus for breaking tolerance and inducing systemic autoimmunity in mice with defective clearance of cell remnants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.