ArticleThe Journal of experimental medicine2005
E47 is required for V(D)J recombinase activity in common lymphoid progenitors.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 85 citations in OpenAlex.
- The Function of E2A in B-Cell Development.Advances in experimental medicine and biology · 2024Review
- Review
- Receptor editing constrains development of phosphatidyl choline-specific B cells in VCell reports · 2022Article
- Helix-Loop-Helix Proteins in Adaptive Immune Development.Frontiers in immunology · 2022Review
- The influence of space and time on the establishment of B cell identity.Biomedical journal · 2019Review
- MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells.International journal of molecular sciences · 2019Article
- The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.Frontiers in immunology · 2019Article
- Corrected and Republished from: BCL11A Is a Critical Component of a Transcriptional Network That Activates RAG Expression and V(D)J Recombination.Molecular and cellular biology · 2018Article
- The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.PLoS genetics · 2017Article
- Sex-, stress-, and sympathetic post-ganglionic-dependent changes in identity and proportions of immune cells in the dura.Cephalalgia : an international journal of headache · 2017Article
- MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.Nature communications · 2016Article
- VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- B cell biology: an overview.Current allergy and asthma reports · 2014Review
- The prenatal origins of cancer.Nature reviews. Cancer · 2014Review
- Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The BCL11A transcription factor directly activates RAG gene expression and V(D)J recombination.Molecular and cellular biology · 2013Article
- Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47.Molecular and cellular biology · 2012Article
- HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.Clinical & developmental immunology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Common lymphoid progenitors (CLPs) are the first bone marrow precursors in which V(D)J recombinase activity is up-regulated. Here, we show that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-J(H) rearrangements in vivo. Apart from a profound arrest before the pro-B cell stage, other downstream lymphoid progeny of CLPs are still intact in these mice albeit at reduced numbers. In contrast to the inhibition of recombinase activity in early B lineage precursors in E47-deficient animals, loss of either E47 or its cis-acting target Erag (enhancer of rag transcription) has little effect on recombinase activity in thymic T lineage precursors. Taken together, this work defines a role for E47 in regulating lineage progression at the CLP stage in vivo and describes the first transcription factor required for lineage-specific recombinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.