ArticleNeuron2005
Adenosine and ATP link PCO2 to cortical excitability via pH.
Article in Neuron, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 221 citations in OpenAlex.
- Neurological Monitoring and Management for Adult Extracorporeal Membrane Oxygenation Patients: Extracorporeal Life Support Organization Consensus Guidelines.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2024Guideline
- Unexpected reductions in regional cerebral perfusion during prolonged hypoxia.The Journal of physiology · 2017Trial
- COeLife · 2026Article
- Hypercapnia dissociates neuronal and hemodynamic responses impairing neurovascular coupling and functional brain connectivity.Nature communications · 2026Article
- Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions.CNS neuroscience & therapeutics · 2025Review
- Maintaining the Quality and Nutritional Integrity of ChilledFoods (Basel, Switzerland) · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy: a case report.Communications medicine · 2025Article
- Inhalation of 5% COActa epileptologica · 2025Article
- Electroencephalographic depression after abruptly increasing partial pressure of end-tidal carbon dioxide: a case series.BMC anesthesiology · 2024Article
- Neurological monitoring and management for adult extracorporeal membrane oxygenation patients: Extracorporeal Life Support Organization consensus guidelines.Critical care (London, England) · 2024Review
- Neurovascular coupling during hypercapnia in cerebral blood flow regulation.Nature communications · 2024Article
- Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons.Neurobiology of disease · 2024Article
- Assessing Acute Brain Injury after Rapid Reduction of PaCONeurocritical care · 2024Article
- Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- The role of NaPflugers Archiv : European journal of physiology · 2024Review
- Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex.Frontiers in pharmacology · 2024Article
- Predicting long-term neurocognitive outcome after pediatric intensive care unit admission for bronchiolitis-preliminary exploration of the potential of machine learning.European journal of pediatrics · 2024Observational
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In addition to affecting respiration and vascular tone, deviations from normal CO(2) alter pH, consciousness, and seizure propensity. Outside the brainstem, however, the mechanisms by which CO(2) levels modify neuronal function are unknown. In the hippocampal slice preparation, increasing CO(2), and thus decreasing pH, increased the extracellular concentration of the endogenous neuromodulator adenosine and inhibited excitatory synaptic transmission. These effects involve adenosine A(1) and ATP receptors and depend on decreased extracellular pH. In contrast, decreasing CO(2) levels reduced extracellular adenosine concentration and increased neuronal excitability via adenosine A(1) receptors, ATP receptors, and ecto-ATPase. Based on these studies, we propose that CO(2)-induced changes in neuronal function arise from a pH-dependent modulation of adenosine and ATP levels. These findings demonstrate a mechanism for the bidirectional effects of CO(2) on neuronal excitability in the forebrain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.