ReviewJournal of cellular and molecular medicine
The telomere length dynamic and methods of its assessment.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.Nature communications · 2019Pooled it
- Genome-wide pervasiveness and localized variation of [Formula: see text]-mer-based genomic signatures in eukaryotes.Scientific reports · 2026Article
- Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate.The Prostate · 2024Article
- Changes in leukocyte telomere length among children with obesity participating in a behavioural weight control program.Pediatric obesity · 2023Article
- Associations between the New DNA-Methylation-Based Telomere Length Estimator, the Mediterranean Diet and Genetics in a Spanish Population at High Cardiovascular Risk.Antioxidants (Basel, Switzerland) · 2023Article
- Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216.Frontiers in physiology · 2021Review
- The telomere length of gastric mucosal samples and peripheral blood lymphocytes in patients who have undergone Billroth II distal gastrectomy.Archives of medical science : AMS · 2020Article
- An Association Study between Longitudinal Changes of Leukocyte Telomere and the Risk of Azoospermia in a Population of Iranian Infertile MenIranian biomedical journal · 2018Article
- The relationship between telomere length and clinicopathologic characteristics in colorectal cancers among Tunisian patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Telomere shortening associated with increased genomic complexity in chronic lymphocytic leukemia.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Dyslipidemia and chronic inflammation markers are correlated with telomere length shortening in Cushing's syndrome.PloS one · 2015Article
- Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood.PloS one · 2015Article
- Telomeric g-tail length and hospitalization for cardiovascular events in hemodialysis patients.Clinical journal of the American Society of Nephrology : CJASN · 2014Observational
- Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.Cancer research · 2014Article
- Telomeres in molecular epidemiology studies.Progress in molecular biology and translational science · 2014Review
- Novel telomere-anchored PCR approach for studying sexual stage telomeres in Aspergillus nidulans.PloS one · 2014Article
- Telomerase activity increased and telomere length shortened in peripheral blood cells from patients with immune thrombocytopenia.Journal of clinical immunology · 2013Article
- Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Telomere biology in hematopoiesis and stem cell transplantation.Blood reviews · 2011Review
- Elevated TRF2 in advanced breast cancers with short telomeres.Breast cancer research and treatment · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human telomeres are composed of long repeating sequences of TTAGGG, associated with a variety of telomere-binding proteins. Its function as an end-protector of chromosomes prevents the chromosome from end-to-end fusion, recombination and degradation. Telomerase acts as reverse transcriptase in the elongation of telomeres, which prevent the loss of telomeres due to the end replication problems. However, telomerase activity is detected at low level in somatic cells and high level in embryonic stem cells and tumor cells. It confers immortality to embryonic stem cells and tumor cells. In most tumor cells, telomeres are extremely short and stable. Telomere length is an important indicator of the telomerase activity in tumor cells and it may be used in the prognosis of malignancy. Thus, the assessment of telomeres length is of great experimental and clinical significance. This review describes the role of telomere and telomerase in cancer pathogenesis and the dynamics of the telomeres length in different cell types. The various methods of measurement of telomeres length, i.e. southern blot, hybridization protection assay, fluorescence in situ hybridization, primed in situ, quantitative PCR and single telomere length analysis are discussed. The principle and comparative evaluation of these methods are reviewed. The detection of G-strand overhang by telomeric-oligonucleotide ligation assay, primer extension/nick translation assay and electron microscopy are briefly discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.