ReviewJournal of cellular and molecular medicine
Embryonic stem cells and cardiomyocyte differentiation: phenotypic and molecular analyses.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 82 citations in OpenAlex.
- Review
- The Trophoblast Compartment Helps Maintain Embryonic Pluripotency and Delays Differentiation towards Cardiomyocytes.International journal of molecular sciences · 2023Article
- Functional and structural phenotyping of cardiomyocytes in the 3D organization of embryoid bodies exposed to arsenic trioxide.Scientific reports · 2021Article
- Tanshinone IIA promotes cardiac differentiation and improves cell motility by modulating the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2020Article
- Cardiomyogenesis of embryonic stem cells upon purinergic receptor activation by ADP and ATP.Purinergic signalling · 2015Article
- eXtraembryonic ENdoderm (XEN) stem cells produce factors that activate heart formation.PloS one · 2010Article
- Effective and steady differentiation of a clonal derivative of P19CL6 embryonal carcinoma cell line into beating cardiomyocytes.Journal of biomedicine & biotechnology · 2010Article
- Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells.Medical & biological engineering & computing · 2009Article
- Engineering tissue from human embryonic stem cells.Journal of cellular and molecular medicine · 2008Review
- beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart.British journal of pharmacology · 2008Article
- Human embryonic stem cell transplantation to repair the infarcted myocardium.Heart (British Cardiac Society) · 2007Article
- Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved.Medical & biological engineering & computing · 2007Review
- Overview of stem cells and imaging modalities for cardiovascular diseases.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2006Review
- Embryonic stem cell bank: a work proposal.Stem cell reviews · 2006Article
- Human cardiomyogenesis and the need for systems biology analysis.Wiley interdisciplinary reviews. Systems biology and medicineReview
- The effect of Cyclosporine A on cardiomyocytes differentiation.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic stem (ES) cell lines, derived from the inner cell mass (ICM) of blastocyst-stage embryos, are pluripotent and have a virtually unlimited capacity for self-renewal and differentiation into all cell types of an embryoproper. Both human and mouse ES cell lines are the subject of intensive investigation for potential applications in developmental biology and medicine. ES cells from both sources differentiate in vitro into cells of ecto-, endoand meso-dermal lineages, and robust cardiomyogenic differentiation is readily observed in spontaneously differentiating ES cells when cultured under appropriate conditions. Molecular, cellular and physiologic analyses demonstrate that ES cell-derived cardiomyocytes are functionally viable and that these cell derivatives exhibit characteristics typical of heart cells in early stages of cardiac development. Because terminal heart failure is characterized by a significant loss of cardiomyocytes, the use of human ES cell-derived progeny represents one possible source for cell transplantation therapies. With these issues in mind, this review will focus on the differentiation of pluripotent embryonic stem cells into cardiomyocytes as a developmental model, and the possible use of ES cell-derived cardiomyocytes as source of donor cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.