Evidence map›Paper›PMID 16362532›Full record

Trial reportJournal of neurology2006

Injection with methylprednisolone in patients with the carpal tunnel syndrome: a randomised double blind trial testing three different doses.

J W H H Dammers, Y Roos, M M Veering, M Vermeulen

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Local corticosteroid injection versus placebo for carpal tunnel syndrome.The Cochrane database of systematic reviews · 2023
    Pooled it
  3. Pooled it
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  5. Local corticosteroid injection for carpal tunnel syndrome.The Cochrane database of systematic reviews · 2007
    Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

J W H H DammersDepartment of Neurology, Medical Centre Alkmaar, 501, 1800 AM, Alkmaar, The Netherlands.
Y Roos
M M Veering
M Vermeulen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the efficacy of 20, 40 and 60 mg methylprednisolone injections in patients with the carpal tunnel syndrome.

methodsIncluded were patients with signs and symptoms of carpal tunnel syndrome of more than 3 months duration confirmed by electrophysiological tests. Patients were in a double blind trial randomised to treatment consisting of injections proximal to the carpal tunnel with 20, 40 or 60 mg methylprednisolone. Primary outcome was improvement of symptoms requiring no further treatment. These patients were followed for one year.

resultsThere were no significant differences in the treatment response between the three randomised groups at one-year follow-up (log rank analysis 1.51, 2 df, 0.4711). In the 20, 40 and 60 mg treatment groups, 56%, 53% and 73% of the patients respectively were free of important symptoms at six months follow-up. Of the patients treated with one or two injections 22% were finally referred to surgery within one year of the first treatment. No side effects were recorded.

conclusionA single local injection of methylprednisolone 20, 40 or 60 mg results in long lasting improvement in approximately half of the patients. There is a trend in favour of the highest dose. A second injection may further reduce the number of patients requiring surgery.

Indexed as

Anti-Inflammatory AgentsCarpal Tunnel SyndromeChi-Square DistributionDose-Response Relationship, DrugDouble-Blind MethodElectrophysiologyFemaleHumansMaleMethylprednisoloneMiddle AgedTime FactorsAnti-Inflammatory AgentsMethylprednisolone

Identifiers

PMID16362532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.