ReviewThe Journal of membrane biology2005
Clinical relevance of ion channels for diagnosis and therapy of cancer.
Review in The Journal of membrane biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 107 citations in OpenAlex.
- The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma.BioMed research international · 2014Trial
- Targeting Ion Channels: Blockers Suppress Calcium Signals and Induce Cytotoxicity Across Medulloblastoma Cell Models.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- The bioelectric mechanisms of local calcium dynamics in cancer cell proliferation: an extension of the A549Frontiers in molecular biosciences · 2024Article
- Ethacrynic Acid: A Promising Candidate for Drug Repurposing as an Anticancer Agent.International journal of molecular sciences · 2023Review
- Exploring the Radioprotective Indium (III) Oxide Screens for Mammography Scans Using a Three-Layer Heterogeneous Breast Phantom and MCNPX: A Comparative Study Using Clinical Findings.Medicina (Kaunas, Lithuania) · 2023Article
- Promoter methylation of transient receptor potential melastatin-related 7 (TRPM7) predicts a better prognosis in patients with Luminal A breast cancers.BMC cancer · 2022Article
- Granzymes-Their Role in Colorectal Cancer.International journal of molecular sciences · 2022Review
- Label-free LC-MS/MS proteomics analyses reveal CLIC1 as a predictive biomarker for bladder cancer staging and prognosis.Frontiers in oncology · 2022Article
- A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.PLoS computational biology · 2021Article
- Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier KThe Journal of membrane biology · 2019Article
- Maftools: efficient and comprehensive analysis of somatic variants in cancer.Genome research · 2018Article
- Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma.Oncotarget · 2018Article
- The Bioelectric Code: Reprogramming Cancer and Aging From the Interface of Mechanical and Chemical Microenvironments.Frontiers in cell and developmental biology · 2018Review
- Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Review
- Regulation of osmolality for cancer treatment.The journal of physiological sciences : JPS · 2017Review
- Critical role of reactive oxygen species (ROS) for synergistic enhancement of apoptosis by vemurafenib and the potassium channel inhibitor TRAM-34 in melanoma cells.Cell death & disease · 2017Article
- The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma.Scientific reports · 2016Article
- Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer.Oncology letters · 2016Article
- Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation.Regeneration (Oxford, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ion channels have a critical role in cell proliferation and it is well documented that channel blockers can inhibit the growth of cancer cells. The concept of ion channels as therapeutic targets or prognostic biomarkers attracts increasing interest, but the lack of potent and selective channel modulators has hampered a critical verification for many years. Today, the knowledge of human ion channel genes is almost complete and molecular correlates for many native currents have already been identified. This information triggered a wave of experimental results, identifying individual ion channels with relevance for specific cancer types. The current pattern of cancer-related ion channels is not arbitrary, but can be reduced to few members from each ion channel family. This review aims to provide an overview of the molecularly identified ion channels that might be relevant for the most common human cancer types. Possible applications of these candidates for a targeted cancer therapy or for clinical diagnosis are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.