ArticleHuman genetics2006
Searching for signals of evolutionary selection in 168 genes related to immune function.
Article in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- HLA class II DRB1, DQA1, DQB1 loci in patients with HIV infection and tuberculosis in a Latvian cohort group.Central-European journal of immunology · 2024Article
- A common allele of HLA mediates asymptomatic SARS-CoV-2 infection.medRxiv : the preprint server for health sciences · 2022Article
- An immunogenetic view of COVID-19.Genetics and molecular biology · 2021Article
- Genome-Wide Scan Identifies Selection Signatures in Chinese Wagyu Cattle Using a High-Density SNP Array.Animals : an open access journal from MDPI · 2019Article
- Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.Genes · 2018Article
- Article
- Detection of selection signatures in dairy and beef cattle using high-density genomic information.Genetics, selection, evolution : GSE · 2015Article
- Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review.Clinical reviews in allergy & immunology · 2015Review
- Genome-wide detection and characterization of positive selection in Korean Native Black Pig from Jeju Island.BMC genetics · 2015Article
- A genome-wide scan for selection signatures in Yorkshire and Landrace pigs based on sequencing data.Animal genetics · 2014Article
- Genome-wide detection of selective signatures in Simmental cattle.Journal of applied genetics · 2014Article
- Evaluating the possibility of detecting evidence of positive selection across Asia with sparse genotype data from the HUGO Pan-Asian SNP Consortium.BMC genomics · 2014Article
- Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution.BMC evolutionary biology · 2014Article
- Applications in the search for genomic selection signatures in fish.Frontiers in genetics · 2014Review
- Common risk alleles for inflammatory diseases are targets of recent positive selection.American journal of human genetics · 2013Article
- Population genetic tools for dissecting innate immunity in humans.Nature reviews. Immunology · 2013Review
- Article
- Using human demographic history to infer natural selection reveals contrasting patterns on different families of immune genes.Proceedings. Biological sciences · 2011Article
- Identifying highly conserved and highly differentiated gene ontology categories in human populations.PloS one · 2011Article
- Extreme evolutionary disparities seen in positive selection across seven complex diseases.PloS one · 2010Article
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Authors and funding
16 authors.
Funding
Abstract
Pathogens have played a substantial role in human evolution, with past infections shaping genetic variation at loci influencing immune function. We selected 168 genes known to be involved in the immune response, genotyped common single nucleotide polymorphisms across each gene in three population samples (CEPH Europeans from Utah, Han Chinese from Guangxi, and Yoruba Nigerians from Southwest Nigeria) and searched for evidence of selection based on four tests for non-neutral evolution: minor allele frequency (MAF), derived allele frequency (DAF), Fst versus heterozygosity and extended haplotype homozygosity (EHH). Six of the 168 genes show some evidence for non-neutral evolution in this initial screen, with two showing similar signals in independent data from the International HapMap Project. These analyses identify two loci involved in immune function that are candidates for having been subject to evolutionary selection, and highlight a number of analytical challenges in searching for selection in genome-wide polymorphism data.
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