ArticleJournal of cancer research and clinical oncology2006
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells.
Article in Journal of cancer research and clinical oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Cathepsin B maturation plays a critical role in leptin-induced hepatic cancer cell growth through activation of NLRP3 inflammasomes.Archives of pharmacal research · 2023Article
- The Role of Cathepsin B in Pathophysiologies of Non-tumor and Tumor tissues: A Systematic Review.Journal of Cancer · 2023Review
- Endosomes, lysosomes, and the role of endosomal and lysosomal biogenesis in cancer development.Molecular biology reports · 2020Review
- Apoptosis and genes involved in oral cancer - a comprehensive review.Oncology reviews · 2020Article
- Role of Cathepsin B as a Marker of Malignant Transformation in Oral Lichen Planus: An Immunohistochemical Study.Journal of clinical and diagnostic research : JCDR · 2017Article
- HIV-infected microglia mediate cathepsin B-induced neurotoxicity.Journal of neurovirology · 2015Article
- Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cathepsin B-deficient mice as source of monoclonal anti-cathepsin B antibodies.Biological chemistry · 2015Article
- Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Disturbance of autophagy-lysosome signaling molecule expression in human gastric adenocarcinoma.Oncology letters · 2014Article
- Article
- Killing a cancer: what are the alternatives?Nature reviews. Cancer · 2012Review
- The negative prognostic value of TRAIL overexpression in oral squamous cell carcinomas does not preclude the potential therapeutic use of recombinant TRAIL.Investigational new drugs · 2012Article
- Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis.PloS one · 2012Article
- Increased expression of stefin B in the nucleus of T98G astrocytoma cells delays caspase activation.Frontiers in molecular neuroscience · 2012Article
- Cell-centric view of apoptosis and apoptotic cell death-inducing antitumoral strategies.Cancers · 2011Article
- Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages.Respiratory research · 2010Article
- Induction of cell death in neuroblastoma by inhibition of cathepsins B and L.Cancer letters · 2010Article
- Non-caspase proteases: triggers or amplifiers of apoptosis?Cellular and molecular life sciences : CMLS · 2010Review
- Lysosomes as "suicide bags" in cell death: myth or reality?The Journal of biological chemistry · 2009Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purposeThe death ligand TRAIL (tumor necrosis factor-related apoptosis inducing ligand) triggers apoptosis in a variety of cancer cells, which implies the potential for therapeutic applications. The purpose of this study was to investigate the role of the lysosomal protease cathepsin B (CB) in mediating TRAIL-induced cell death in oral squamous cell carcinoma (OSCC) cells.
methodsOSCC cell lines from primary tumor and lymph node metastasis were examined for expression of apoptosis markers by Western blots, enzyme activity assays, nuclear fragmentation assays, and FACS analysis. Gene-specific ribozymes or chemical inhibitors were used to inhibit CB or caspases in target cells.
resultsTRAIL-induced activation of caspase-3, cleavage of Bid and poly-ADP-ribose polymerase, release of cytochrome c, and DNA fragmentation were blocked either by a pan-caspase inhibitor (zVAD-fmk) or a CB inhibitor (CA074Me), consistent with the involvement of TRAIL as well as CB in cell death. The primary tumor cells were more susceptible to apoptosis than their corresponding lymph node metastatic cells. Stable transfection of a ribozyme which inhibited CB expression also decreased the apoptotic process.
conclusionsWe conclude that TRAIL-induced apoptotic cell death in OSCC cells is mediated through CB or through caspase activation. Our data point to a new tumor-suppressive role for CB in OSCC which is opposed to the invasion- and metastasis-promoting functions of lysosomal proteases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.