ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2006
Cyclooxygenase 1 and 2 expressions in the human thyroid gland.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- The Role of Lipid Metabolism Disorders in the Development of Thyroid Cancer.International journal of molecular sciences · 2024Review
- Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions.Pathology oncology research : POR · 2016Article
- Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre.Thyroid research · 2014Article
- High COX-2 immunostaining in papillary thyroid carcinoma is associated with adverse survival outcomes.Annals of Saudi medicineArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.
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