ArticlePLoS computational biology2005
Selective constraint on noncoding regions of hominid genomes.
Article in PLoS computational biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Impact of loci nature on estimating recombination and mutation rates in Chlamydia trachomatis.G3 (Bethesda, Md.) · 2012Article
- New words in human mutagenesis.BMC bioinformatics · 2011Article
- Evolutionary evidence of the effect of rare variants on disease etiology.Clinical genetics · 2011Review
- Unravelling cis-regulatory elements in the genome of the smallest photosynthetic eukaryote: phylogenetic footprinting in Ostreococcus.Journal of molecular evolution · 2009Article
- Evolutionary processes acting on candidate cis-regulatory regions in humans inferred from patterns of polymorphism and divergence.PLoS genetics · 2009Article
- Article
- Widespread ultraconservation divergence in primates.Molecular biology and evolution · 2008Article
- Fast evolution of core promoters in primate genomes.Molecular biology and evolution · 2008Article
- A genome-wide screen for noncoding elements important in primate evolution.BMC evolutionary biology · 2008Article
- Transcription-related mutations and GC content drive variation in nucleotide substitution rates across the genomes of Arabidopsis thaliana and Arabidopsis lyrata.BMC evolutionary biology · 2007Article
- Patterns and rates of intron divergence between humans and chimpanzees.Genome biology · 2007Article
- What makes us human: revisiting an age-old question in the genomic era.Journal of biomedical discovery and collaboration · 2006Article
- Evolutionary turnover of mammalian transcription start sites.Genome research · 2006Article
- Understanding the degradation of hominid gene control.PLoS computational biology · 2006Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important challenge for human evolutionary biology is to understand the genetic basis of human-chimpanzee differences. One influential idea holds that such differences depend, to a large extent, on adaptive changes in gene expression. An important step in assessing this hypothesis involves gaining a better understanding of selective constraint on noncoding regions of hominid genomes. In noncoding sequence, functional elements are frequently small and can be separated by large nonfunctional regions. For this reason, constraint in hominid genomes is likely to be patchy. Here we use conservation in more distantly related mammals and amniotes as a way of identifying small sequence windows that are likely to be functional. We find that putatively functional noncoding elements defined in this manner are subject to significant selective constraint in hominids.
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