ArticleThe British journal of ophthalmology2006
Expression of glutamine synthetase and cell proliferation in human idiopathic epiretinal membrane.
Article in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Topographic relationship between glial cells and neovessels of the epiretinal membrane in proliferative diabetic retinopathy depends on the phase of angiogenesis.Frontiers in cellular neuroscience · 2025Article
- Immunohistochemical, functional, and anatomical evaluation of patients with idiopathic epiretinal membrane.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- MicroRNA-494 augments fibrotic transformation of human retinal pigment epithelial cells and targets p27 with cell-type specificity.Frontiers in ophthalmology · 2023Article
- Cellular components of the idiopathic epiretinal membrane.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Review
- [Proliferative vitreoretinopathy (PVR) minimal: same, same but different. Characteristics and surgical treatment of PVR-associated macular pucker].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2021Review
- TGF-β-SNAIL axis induces Müller glial-mesenchymal transition in the pathogenesis of idiopathic epiretinal membrane.Scientific reports · 2019Article
- Microscopic Observation of Proliferative Membranes in Fibrocontractive Retinal Disorders.Journal of ophthalmology · 2019Article
- Quantification of changes in foveal capillary architecture caused by idiopathic epiretinal membrane using OCT angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Observational
- Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane.Scientific reports · 2017Article
- Epiretinal membrane: optical coherence tomography-based diagnosis and classification.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Comparison of the Effectiveness of Pars Plana Vitrectomy with and without Internal Limiting Membrane Peeling for Idiopathic Retinal Membrane Removal: A Meta-Analysis.Journal of ophthalmology · 2015Review
- Current Trends about Inner Limiting Membrane Peeling in Surgery for Epiretinal Membranes.Journal of ophthalmology · 2015Review
- Inflammatory mechanisms of idiopathic epiretinal membrane formation.Mediators of inflammation · 2013Review
- Expression of erythropoietin receptor in human epiretinal membrane of proliferative diabetic retinopathy.The British journal of ophthalmology · 2007Article
- Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium.The British journal of ophthalmology · 2007Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimThe mechanisms of the cellular origin and cell proliferation in the idiopathic epiretinal membrane (ERM) are unsolved. The aim of this study was to examine the expression of cell cycle related molecules and glutamine synthetase (GS), which is expressed in Müller cells and their processes, in ERM tissues.
methodsThe ERMs were surgically removed using pars plana vitrectomy. Formalin fixed, paraffin embedded ERM tissues were analysed by immunohistochemistry with anti-cyclin D1, p27 (KIP1), proliferating cell nuclear antigen (PCNA), and GS antibodies.
resultsThe histopathological findings showed that all the ERMs consisted of oval or spindle mononuclear cells with thin collagen-like tissues. Immunoreactivity for GS was detected in collagen-like tissues of ERM, presenting a continuous, isodense pattern. GS immunopositive cells in all cases expressed PCNA in their nuclei. Nuclear immunoreactivity for cyclin D1 was noted in the ERM constituent cells, whereas p27 (KIP1) positive nuclei were not detected.
conclusionCyclin D1 and PCNA were expressed in the idiopathic ERM, which was mainly derived from Müller cells and extensions of their processes.
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