ArticlePlant physiology2006
Organ-specific expression of glutathione S-transferases and the efficacy of herbicide safeners in Arabidopsis.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Selective herbicide safening in dicot plants: a case study inFrontiers in plant science · 2023Article
- The GlutathioneInternational journal of molecular sciences · 2022Article
- Mechanism of Resistance toFrontiers in plant science · 2021Article
- Effects of fenclorim on rice physiology, gene transcription and pretilachlor detoxification ability.BMC plant biology · 2020Article
- Transcriptome Profiling and Genome-Wide Association Studies RevealFrontiers in plant science · 2019Article
- Herbicide Safeners Decrease Sensitivity to Herbicides Inhibiting Acetolactate-Synthase and Likely Activate Non-Target-Site-Based Resistance Pathways in the Major Grass WeedFrontiers in plant science · 2017Article
- Compartment-specific importance of glutathione during abiotic and biotic stress.Frontiers in plant science · 2014Article
- Protective responses induced by herbicide safeners in wheat.Environmental and experimental botany · 2013Article
- High resolution imaging of subcellular glutathione concentrations by quantitative immunoelectron microscopy in different leaf areas of Arabidopsis.Micron (Oxford, England : 1993) · 2013Article
- Subcellular distribution of glutathione precursors in Arabidopsis thaliana.Journal of integrative plant biology · 2011Article
- Xenobiotic responsiveness of Arabidopsis thaliana to a chemical series derived from a herbicide safener.The Journal of biological chemistry · 2011Article
- Glutathione synthesis is essential for pollen germination in vitro.BMC plant biology · 2011Article
- A glutathione S-transferase regulated by light and hormones participates in the modulation of Arabidopsis seedling development.Plant physiology · 2010Article
- Subcellular compartmentation of glutathione in dicotyledonous plants.Protoplasma · 2010Article
- Detoxification without intoxication: herbicide safeners activate plant defense gene expression.Plant physiology · 2010Review
- Glutathione transferases.The arabidopsis book · 2010Article
- Subcellular immunocytochemical analysis detects the highest concentrations of glutathione in mitochondria and not in plastids.Journal of experimental botany · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The functions of plant glutathione S-transferases (GSTs) under normal growth conditions are poorly understood, but their activity as detoxification enzymes has been harnessed in agriculture for selective weed control. Herbicide safeners protect monocot crops from herbicide injury but have little effect on weedy monocot or dicot species. Protection by safeners is associated with expression of herbicide-metabolizing enzymes including GSTs, but the basis for selective action of safeners between monocots and dicots is not known. To address this question we have studied the response of Arabidopsis (Arabidopsis thaliana) to various safeners. Benoxacor, fenclorim, and fluxofenim did not protect Arabidopsis from herbicide injury but did induce RNA expression of the glutathione-conjugate transporters encoded by AtMRP1, AtMRP2, AtMRP3, and AtMRP4. These safeners also induced the organ-specific expression of AtGSTU19 and AtGSTF2, two previously characterized Arabidopsis GSTs from different classes of this enzyme family. RNA hybridization, immunoblot, and reporter gene analyses indicated expression of AtGSTU19 induced by safeners predominated in roots. To test the hypothesis that increased expression of AtGSTU19 would be sufficient to provide tolerance to chloroacetamide herbicides, a chimeric gene was produced containing the open reading frame for this GST driven by a constitutive promoter. Plants containing this transgene had a modest increase in AtGSTU19 protein, predominantly in roots, but this had no effect on tolerance to chloroacetamide herbicides. The localized induction of GSTs by safeners in roots of Arabidopsis may explain why these compounds are unable to provide herbicide tolerance to dicot plant species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.