ArticleProceedings of the National Academy of Sciences of the United States of America2005
Structural basis for conductance by the archaeal aquaporin AqpM at 1.68 A.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 161 citations in OpenAlex.
- Amino Acid Substitutions in Loop C of Arabidopsis PIP2 Aquaporins Alters the Permeability of COPlant, cell & environment · 2025Article
- Genome-Wide Dissection of MATE Gene Family in Cultivated Peanuts and Unveiling Their Expression Profiles Under Aluminum Stress.International journal of molecular sciences · 2025Article
- Alternative sources of molybdenum for Methanococcus maripaludis and their implication for the evolution of molybdoenzymes.Communications biology · 2024Article
- Evolutionary Overview of Aquaporin Superfamily.Advances in experimental medicine and biology · 2023Article
- Protein Structure and Modification of Aquaporins.Advances in experimental medicine and biology · 2023Article
- Aquaporin Gating: A New Twist to Unravel Permeation through Water Channels.International journal of molecular sciences · 2022Review
- Sulfur Compounds in Regulation of Stomatal Movement.Frontiers in plant science · 2022Review
- Structural basis for high selectivity of a rice silicon channel Lsi1.Nature communications · 2021Article
- Aquaglyceroporin AqpS from Sinorhizobium meliloti conducts both trivalent and pentavalent methylarsenicals.Chemosphere · 2021Article
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- Prokaryotic Aquaporins.Cells · 2019Review
- GPathFinder: Identification of Ligand-Binding Pathways by a Multi-Objective Genetic Algorithm.International journal of molecular sciences · 2019Article
- Identification and characterization of aquaporin genes in Arachis duranensis and Arachis ipaensis genomes, the diploid progenitors of peanut.BMC genomics · 2019Article
- Variation in Aquaporin and Physiological Responses AmongPlants (Basel, Switzerland) · 2019Article
- Human adipose glycerol flux is regulated by a pH gate in AQP10.Nature communications · 2018Article
- Genome-Wide Analysis of Multidrug and Toxic Compound Extrusion (G3 (Bethesda, Md.) · 2018Article
- Aquaporin-graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination.Interface focus · 2018Review
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- Plant and animal aquaporins crosstalk: what can be revealed from distinct perspectives.Biophysical reviews · 2017Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To explore the structural basis of the unique selectivity spectrum and conductance of the transmembrane channel protein AqpM from the archaeon Methanothermobacter marburgensis, we determined the structure of AqpM to 1.68-A resolution by x-ray crystallography. The structure establishes AqpM as being in a unique subdivision between the two major subdivisions of aquaporins, the water-selective aquaporins, and the water-plus-glycerol-conducting aquaglyceroporins. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.