ArticleBiophysical journal2006
Confinement effects on the thermodynamics of protein folding: Monte Carlo simulations.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Genetic Functionalization of Protein-Based Biomaterials via Protein Fusions.Biomacromolecules · 2024Review
- Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics.The journal of physical chemistry letters · 2023Article
- Hydrogel Delivery Device for the In Vitro and In Vivo Sustained Release of Active rhGALNS Enzyme.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Enzyme immobilization studied through molecular dynamic simulations.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Stability of proteins encapsulated in Michael-type addition polyethylene glycol hydrogels.Biotechnology and bioengineering · 2021Article
- The exclusive effects of chaperonin on the behavior of proteins with 52 knot.PLoS computational biology · 2018Article
- Knotting and unknotting proteins in the chaperonin cage: Effects of the excluded volume.PloS one · 2017Article
- Combined effect of confinement and affinity of crowded environment on conformation switching of adenylate kinase.Journal of molecular modeling · 2014Article
- Conformational sampling of peptides in the presence of protein crowders from AA/CG-multiscale simulations.The journal of physical chemistry. B · 2012Article
- Power-law dependence of the melting temperature of ubiquitin on the volume fraction of macromolecular crowders.The Journal of chemical physics · 2011Article
- Reconciling theories of chaperonin accelerated folding with experimental evidence.Cellular and molecular life sciences : CMLS · 2010Review
- Monte Carlo simulations of proteins in cages: influence of confinement on the stability of intermediate states.Biophysical journal · 2009Article
- Thermodynamics and kinetics of protein folding under confinement.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Development of free-energy-based models for chaperonin containing TCP-1 mediated folding of actin.Journal of the Royal Society, Interface · 2008Review
- An entropic perspective of protein stability on surfaces.Biophysical journal · 2008Article
- Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences.Annual review of biophysics · 2008Review
- Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues.Biotechnology advancesReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The effects of chaperonin-like cage-induced confinement on protein stability have been studied for molecules of varying sizes and topologies. Minimalist models based on Gō-like interactions are employed for the proteins, and density-of-states-based Monte Carlo simulations are performed to accurately characterize the thermodynamic transitions. This method permits efficient sampling of conformational space and yields precise estimates of free energy and entropic changes associated with protein folding. We find that confinement-driven stabilization is not only dependent on protein size and cage radius, but also on the specific topology. The choice of the confining potential is also shown to have an effect on the observed stabilization and the scaling behavior of the stabilization with respect to the cage size.
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