ArticleInternational immunology2006
Activation of Vgamma9Vdelta2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication.
Article in International immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The trial behind it
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- The pulmonary commensal Lactobacillus regulated lung γδ T cells to enhance resistance against bacterial infections.Microbiome · 2025Article
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- Defying convention in the time of COVID-19: Insights into the role of γδ T cells.Frontiers in immunology · 2022Review
- Role of Vγ9vδ2 T lymphocytes in infectious diseases.Frontiers in immunology · 2022Review
- Crosstalk between γδ T cells and the microbiota.Nature microbiology · 2021Review
- A Cell for the Ages: Human γδ T Cells across the Lifespan.International journal of molecular sciences · 2020Review
- Role of γδ T cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches.Virology journal · 2020Review
- Lymphocyte Landscape after ChronicInternational journal of molecular sciences · 2020Review
- Diverse Functions of γδ T Cells in the Progression of Hepatitis B Virus and Hepatitis C Virus Infection.Frontiers in immunology · 2020Review
- Persistent gamma delta T-cell dysfunction in chronic HCV infection despite direct-acting antiviral therapy induced cure.Journal of viral hepatitis · 2019Article
- Review
- γδ T-cell responses during HIV infection and antiretroviral therapy.Clinical & translational immunology · 2019Review
- γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ.Current medical science · 2018Article
- γδ T cells in liver diseases.Frontiers of medicine · 2018Review
- Unique and Common Features of Innate-Like Human Vδ2Frontiers in immunology · 2018Article
- Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy.Frontiers in immunology · 2018Article
- Protective Role ofJournal of immunology research · 2018Review
- γδ T Lymphocytes: An Effector Cell in Autoimmunity and Infection.Frontiers in immunology · 2018Review
- Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) has evolved complex strategies to evade host immune responses and establish chronic infection. Since human Vgamma9Vdelta2 T lymphocytes play a critical role in the immune response against viruses, we analyzed their antiviral functions on Huh7 hepatoma cells carrying the subgenomic HCV replicon (Rep60 cells). In a transwell culture system, Rep60 cells were co-cultured with either PBMCs or highly purified gammadelta T cells stimulated by non-peptidic antigens. Vgamma9Vdelta2 T cell activation was associated with a dramatic reduction of HCV RNA levels. Neutralizing antibodies targeting IFN-gamma revealed a critical role for this cytokine in the inhibition of HCV replication. Interestingly, drugs already in clinical use, such as Phosphostim and Zoledronate, known to activate gammadelta T cells, were shown to induce the inhibition of HCV replication mediated by Vgamma9Vdelta2 T cells of HCV patients. Our data suggest that the therapeutic activation of Vgamma9Vdelta2 T lymphocytes may represent an additional strategy to inhibit HCV replication and to restore a Th1-oriented immune response in HCV-infected patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.