ArticleGenetics2006
Evolutionary rates and expression level in Chlamydomonas.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Stabilizing and directional selection shape the genetic variation of gene expression in the transcriptome of Chlamydomonas.Molecular biology and evolution · 2026Article
- De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas.Molecular biology and evolution · 2021Article
- Comparative genomics of Chlamydomonas.The Plant cell · 2021Article
- Abundance Imparts Evolutionary Constraints of Similar Magnitude on the Buried, Surface, and Disordered Regions of Proteins.Frontiers in molecular biosciences · 2021Article
- Evolutionary rate variation among genes involved in galactomannan biosynthesis inEcology and evolution · 2020Article
- Codon and Amino Acid Usage Are Shaped by Selection Across Divergent Model Organisms of the Pancrustacea.G3 (Bethesda, Md.) · 2015Article
- Comparative investigation of the various determinants that influence the codon and amino acid usage patterns in the genus Bifidobacterium.World journal of microbiology & biotechnology · 2015Article
- Transcriptional abundance is not the single force driving the evolution of bacterial proteins.BMC evolutionary biology · 2013Article
- Three independent determinants of protein evolutionary rate.Journal of molecular evolution · 2013Review
- Flagellated algae protein evolution suggests the prevalence of lineage-specific rules governing evolutionary rates of eukaryotic proteins.Genome biology and evolution · 2013Article
- Evolutionary rate heterogeneity of core and attachment proteins in yeast protein complexes.Genome biology and evolution · 2013Article
- Determinants of exon-level evolutionary rates in Arabidopsis species.Evolutionary bioinformatics online · 2012Article
- Codon Usage Patterns in Corynebacterium glutamicum: Mutational Bias, Natural Selection and Amino Acid Conservation.Comparative and functional genomics · 2010Article
- Evolutionary rate patterns of the Gibberellin pathway genes.BMC evolutionary biology · 2009Article
- Cysteine modification of a specific repressor protein controls the translational status of nucleus-encoded LHCII mRNAs in Chlamydomonas.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.Cell · 2008Article
- Nucleotide diversity in the mitochondrial and nuclear compartments of Chlamydomonas reinhardtii: investigating the origins of genome architecture.BMC evolutionary biology · 2008Article
- Identification of the minus-dominance gene ortholog in the mating-type locus of Gonium pectorale.Genetics · 2008Article
- Between-species analysis of short-repeat modules in cell wall and sex-related hydroxyproline-rich glycoproteins of Chlamydomonas.Plant physiology · 2007Article
- Mitochondrial genome sequence evolution in Chlamydomonas.Genetics · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In many biological systems, especially bacteria and unicellular eukaryotes, rates of synonymous and nonsynonymous nucleotide divergence are negatively correlated with the level of gene expression, a phenomenon that has been attributed to natural selection. Surprisingly, this relationship has not been examined in many important groups, including the unicellular model organism Chlamydomonas reinhardtii. Prior to this study, comparative data on protein-coding sequences from C. reinhardtii and its close noninterfertile relative C. incerta were very limited. We compiled and analyzed protein-coding sequences for 67 nuclear genes from these taxa; the sequences were mostly obtained from the C. reinhardtii EST database and our C. incerta EST data. Compositional and synonymous codon usage biases varied among genes within each species but were highly correlated between the orthologous genes of the two species. Relative rates of synonymous and nonsynonymous substitution across genes varied widely and showed a strong negative correlation with the level of gene expression estimated by the codon adaptation index. Our comparative analysis of substitution rates in introns of lowly and highly expressed genes suggests that natural selection has a larger contribution than mutation to the observed correlation between evolutionary rates and gene expression level in Chlamydomonas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.