ArticleGenetics2006
Variable pleiotropic effects from mutations at the same locus hamper prediction of fitness from a fitness component.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Survival of Thermostable Φ6 Genotypes in Acidic, Basic, and UV Environments.bioRxiv : the preprint server for biology · 2025Article
- Adaptation of turnip mosaic virus toVirus evolution · 2024Article
- Additive Phenotypes Underlie Epistasis of Fitness Effects.Genetics · 2018Article
- Coat Protein Mutations That Alter the Flux of Morphogenetic Intermediates through the ϕX174 Early Assembly Pathway.Journal of virology · 2017Article
- Genetically Determined Variation in Lysis Time Variance in the Bacteriophage φX174.G3 (Bethesda, Md.) · 2016Article
- Modularity: genes, development and evolution.Annual review of ecology, evolution, and systematics · 2016Article
- Intergenic incompatibilities reduce fitness in hybrids of extremely closely related bacteriophages.PeerJ · 2015Article
- The adaptive potential of hybridization demonstrated with bacteriophages.Journal of molecular evolution · 2013Article
- The consistency of beneficial fitness effects of mutations across diverse genetic backgrounds.PloS one · 2012Article
- Epistasis between beneficial mutations and the phenotype-to-fitness Map for a ssDNA virus.PLoS genetics · 2011Article
- Identifying genetic markers of adaptation for surveillance of viral host jumps.Nature reviews. Microbiology · 2010Review
- Bacteriophage PhiX174's ecological niche and the flexibility of its Escherichia coli lipopolysaccharide receptor.Applied and environmental microbiology · 2010Article
- Experimental evolution of viruses: Microviridae as a model system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Article
- Genic incompatibilities in two hybrid bacteriophages.Molecular biology and evolution · 2009Article
- Bacteriophages as model organisms for virus emergence research.Trends in microbiology · 2009Review
- High-resolution mapping of evolutionary trajectories in a phage.Genome biology and evolution · 2009Article
- Beneficial fitness effects are not exponential for two viruses.Journal of molecular evolution · 2008Article
- Impact of individual mutations on increased fitness in adaptively evolved strains of Escherichia coli.Journal of bacteriology · 2008Article
- Experimental evolution and genome sequencing reveal variation in levels of clonal interference in large populations of bacteriophage phiX174.BMC evolutionary biology · 2008Article
- Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.Genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The relationship of genotype, fitness components, and fitness can be complicated by genetic effects such as pleiotropy and epistasis and by heterogeneous environments. However, because it is often difficult to measure genotype and fitness directly, fitness components are commonly used to estimate fitness without regard to genetic architecture. The small bacteriophage X174 enables direct evaluation of genetic and environmental effects on fitness components and fitness. We used 15 mutants to study mutation effects on attachment rate and fitness in six hosts. The mutants differed from our lab strain of X174 by only one or two amino acids in the major capsid protein (gpF, sites 101 and 102). The sites are variable in natural and experimentally evolved X174 populations and affect phage attachment rate. Within the limits of detection of our assays, all mutations were neutral or deleterious relative to the wild type; 11 mutants had decreased host range. While fitness was predictable from attachment rate in most cases, 3 mutants had rapid attachment but low fitness on most hosts. Thus, some mutations had a pleiotropic effect on a fitness component other than attachment rate. In addition, on one host most mutants had high attachment rate but decreased fitness, suggesting that pleiotropic effects also depended on host. The data highlight that even in this simple, well-characterized system, prediction of fitness from a fitness component depends on genetic architecture and environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.