ArticleCell2005
Chromosome sites play dual roles to establish homologous synapsis during meiosis in C. elegans.
Article in Cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.
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Who cites it
217 citing papers in PubMed.
- Nuclear envelope buffering of cytoskeletal force stabilizes chromosome interactions inbioRxiv : the preprint server for biology · 2026Article
- The mid-pachytene transition between early and late double-strand breaks in C. elegans meiosis is conserved throughout early adulthood and coincides with a peak in recombination intermediates.G3 (Bethesda, Md.) · 2026Article
- High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures.PLoS genetics · 2026Article
- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
- Disordered protein COSA-2 maintains crossover-specific repair compartments to ensure meiotic crossover maturation.bioRxiv : the preprint server for biology · 2026Article
- Structure and function of the synaptonemal complex.The Journal of cell biology · 2026Review
- High-resolution global recombination mapping inbioRxiv : the preprint server for biology · 2026Article
- The tiny germline chromosomes of Paramecium aurelia have an exceptionally high recombination rate and are capped by a new class of Helitrons.BMC biology · 2026Article
- Early resolution of sister chromatids during C. elegans meiosis.The Journal of cell biology · 2026Article
- Kinetic analysis of strand invasion intermediates during C. elegans meiosis reveals continuous sister- and homolog-directed repair.Genetics · 2026Article
- Active maintenance of meiosis-specific chromosome structures inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Orchestrating homolog segregation in meiosis I: molecular logic and regulatory networks with emphasis on male metaphase I.Cell communication and signaling : CCS · 2026Review
- Forceful Beginnings: Mechanotransduction and Mechanosensation at the Meiotic Cell Nucleus During Gamete Development.Results and problems in cell differentiation · 2026Review
- Article
- Multi-step implementation of meiotic crossover patterning.bioRxiv : the preprint server for biology · 2025Article
- Bloom helicase contributes to successful crossover formation with both catalytic and structural roles in Caenorhabditis elegans meiosis.Nucleic acids research · 2025Article
- A DNA-containing phase-separated compartment links the nuclear envelope to chromosome axes to promote homolog pairing inScience advances · 2025Article
- Active maintenance of meiosis-specific chromosome structures inbioRxiv : the preprint server for biology · 2025Article
- Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.PLoS genetics · 2025Article
- Crossover patterning through condensation and coarsening of pro-crossover factors.Nature cell biology · 2025Article
157 more citing papers are in PubMed but not listed here.
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6 authors.
Funding
Abstract
We have investigated the role of pairing centers (PCs), cis-acting sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans. We find that these sites play two distinct roles that contribute to proper segregation. Chromosomes lacking PCs usually fail to synapse and also lack a synapsis-independent stabilization activity. The presence of a PC on just one copy of a chromosome pair promotes synapsis but does not support synapsis-independent pairing stabilization, indicating that these functions are separable. Once initiated, synapsis is highly processive, even between nonhomologous chromosomes of disparate lengths, elucidating how translocations suppress meiotic recombination in C. elegans. These findings suggest a multistep pathway for chromosome synapsis in which PCs impart selectivity and efficiency through a "kinetic proofreading" mechanism. We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability.
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