ArticleGenes & development2005
Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila.
Article in Genes & development, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- Transcriptional repression of Myc underlies the tumour suppressor function of AGO1 inDevelopment (Cambridge, England) · 2020Article
- High MYC Levels Favour Multifocal Carcinogenesis.Frontiers in genetics · 2018Article
- Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.Nature communications · 2015Article
- MYC association with cancer risk and a new model of MYC-mediated repression.Cold Spring Harbor perspectives in medicine · 2014Review
- Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.The Journal of biological chemistry · 2014Article
- An overview of MYC and its interactome.Cold Spring Harbor perspectives in medicine · 2014Review
- The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth.Development (Cambridge, England) · 2013Article
- Myc function in Drosophila.Cold Spring Harbor perspectives in medicine · 2013Review
- Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.Developmental biology · 2013Article
- Direct reprogramming by oncogenic Ras and Myc.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase.Cancer research · 2013Article
- The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.PLoS genetics · 2013Article
- The immediate early gene product EGR1 and polycomb group proteins interact in epigenetic programming during chondrogenesis.PloS one · 2013Article
- pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases.Molecules and cells · 2012Article
- Identification of cis-Regulatory Elements in the dmyc Gene of Drosophila Melanogaster.Gene regulation and systems biology · 2012Article
- Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells.Epigenetics & chromatin · 2011Article
- Enzymatic assays for assessing histone deubiquitylation activity.Methods (San Diego, Calif.) · 2011Article
- Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.PloS one · 2011Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aberrant accumulation of the Myc oncoprotein propels proliferation and induces carcinogenesis. In normal cells, however, an abundance of Myc protein represses transcription at the c-myc locus. Cancer cells often lose this autorepression. We examined the control of myc in Drosophila and show here that the Drosophila ortholog, dmyc, also undergoes autorepression. We find that the developmental repressor Polycomb (Pc) is required for dmyc autorepression, and that this Pc-dMyc-mediated repression spreads across an 875-kb region encompassing the dmyc gene. To further investigate the relationship between Myc and Polycomb, we used microarrays to identify genes regulated by each, and identify a striking relationship between the two: A large set of dMyc activation targets is normally repressed by Pc, and 73% of dMyc repression targets require Pc for this repression. Chromatin immunoprecipitation confirmed that many dMyc-Pc-repressed loci have an epigenetic mark recognized by Pc. Our results suggest a novel relationship between Myc and Polycomb, wherein Myc enhances Polycomb repression in order to repress targets, and Myc suppresses Polycomb repression in order to activate targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.