ArticleProceedings of the National Academy of Sciences of the United States of America2005
Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
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- Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.Communications biology · 2024Article
- Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity.Redox biology · 2024Article
- Molecular and cellular mechanisms of developmental synapse elimination in the cerebellum: Involvement of autism spectrum disorder-related genes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
- C1ql1-Bai3 signaling is necessary for climbing fiber synapse formation in mature Purkinje cells in coordination with neuronal activity.Molecular brain · 2023Article
- Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour.Nature communications · 2022Article
- Contribution of tetrodotoxin-resistant persistent NaThe journal of headache and pain · 2022Article
- Suppression of Pain in the Late Phase of Chronic Trigeminal Neuropathic Pain Failed to Rescue the Decision-Making Deficits in Rats.International journal of molecular sciences · 2021Article
- The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice.Molecular brain · 2021Article
- Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target.Science advances · 2021Article
- Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.Scientific reports · 2020Article
- Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex.Scientific reports · 2019Article
- Maturation, Refinement, and Serotonergic Modulation of Cerebellar Cortical Circuits in Normal Development and in Murine Models of Autism.Neural plasticity · 2017Review
- Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.The Journal of clinical investigation · 2016Article
- Sculpting neural circuits by axon and dendrite pruning.Annual review of cell and developmental biology · 2015Review
- Synapse elimination in the developing cerebellum.Cellular and molecular life sciences : CMLS · 2013Review
- Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development.The Journal of physiology · 2013Review
- Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Rewiring of afferent fibers in the somatosensory thalamus of mice caused by peripheral sensory nerve transection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Activity-dependent synaptic modification occurs in both developing and mature animals. For reliable information transfer and storage, however, once established, synapses must be maintained stably. We investigated how chronic blockade of neuronal activity or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors affects excitatory climbing fiber (CF) to Purkinje cell (PC) synapses in adult mouse cerebellum. Both treatments caused reduced glutamate concentration transient at the synaptic cleft, decreased frequency of quantal excitatory postsynaptic current, and diminished CF innervation of PC shaft dendrites but no change in CF's release probability. These results indicate that, in the mature cerebellum, AMPA receptor-mediated excitatory postsynaptic activity maintains CF's functional glutamate-release sites and its innervation of PC shaft dendrites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.