ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2006
Dystroglycan receptor is involved in integrin activation in intestinal epithelia.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- A dystroglycan-laminin-integrin axis coordinates cell shape remodeling in the developing Drosophila retina.PLoS biology · 2024Article
- Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.Journal of virology · 2016Article
- Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity.Journal of cell science · 2014Article
- Recent advances in small bowel diseases: Part I.World journal of gastroenterology · 2012Review
- MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation.The Journal of biological chemistry · 2010Article
- Biological role of dystroglycan in Schwann cell function and its implications in peripheral nervous system diseases.Journal of biomedicine & biotechnology · 2010Review
- Dystrobrevin and dystrophin family gene expression in zebrafish.Gene expression patterns : GEP · 2008Article
- Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells.Cancer research · 2007Article
- Extracellular interaction between hCD98 and the PDZ class II domain of hCASK in intestinal epithelia.The Journal of membrane biology · 2007Article
- Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion.Journal of molecular biology · 2006Article
- Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring.Journal of cell science · 2006Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The dystroglycans (alpha-DG and beta-DG), which play important roles in the formation of basement membranes, have been well studied in skeletal muscle and nerve, but their expression and localization in intestinal epithelial cells has not been previously investigated. Here, we demonstrated that the DG complex, composed of alpha-DG, beta-DG, and utrophin, is specifically expressed in the basolateral membrane of the Caco-2-BBE monolayer. The DG complex coprecipitated with beta(1)-integrin, suggesting a possible interaction among these proteins. In addition, we observed that activation of DG receptors by laminin-1 enhanced the interaction between beta(1)-integrin and laminin-1, whereas activation of DG receptors by laminin-2 reduced the interaction between beta(1)-integrin and laminin-2. Finally, we demonstrated that the intracellular COOH-terminal tail of beta-DG and its binding to the DG binding domain of utrophin are crucial for the interactions between laminin-1/-2 and beta(1)-integrin. Collectively, these novel results indicate that dystroglycans play important roles in the regulation of interactions between intestinal epithelial cells and the extracellular matrix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.