ArticleNucleic acids research2005
Structure and energy of a DNA dodecamer under tensile load.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The emergence of sequence-dependent structural motifs in stretched, torsionally constrained DNA.Nucleic acids research · 2020Article
- Piezoresistivity in single DNA molecules.Nature communications · 2015Article
- The transition mechanism of DNA overstretching: a microscopic view using molecular dynamics.Journal of the Royal Society, Interface · 2014Article
- B-DNA to zip-DNA: simulating a DNA transition to a novel structure with enhanced charge-transport characteristics.The journal of physical chemistry. A · 2011Article
- Biophysical characterization of DNA binding from single molecule force measurements.Physics of life reviews · 2010Review
- A three-state model with loop entropy for the overstretching transition of DNA.Biophysical journal · 2010Article
- Stretched DNA investigated using molecular-dynamics and quantum-mechanical calculations.Biophysical journal · 2010Article
- Force-driven separation of short double-stranded DNA.Biophysical journal · 2009Article
- Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Review
- DNA overstretching in the presence of glyoxal: structural evidence of force-induced DNA melting.Biophysical journal · 2008Article
- Modulation of T4 gene 32 protein DNA binding activity by the recombination mediator protein UvsY.Journal of molecular biology · 2008Article
- Force-induced structural transitions in cross-linked DNA films.European biophysics journal : EBJ · 2008Article
- Simulation of the mechanical strength of a single collagen molecule.Biophysical journal · 2008Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last decade, methods to study single DNA molecules under tensile load have been developed. These experiments measure the force required to stretch and melt the double helix and provide insights into the structural stability of DNA. However, it is not easy to directly relate the shape of the force curve to the structural changes that occur in the double helix under tensile load. Here, state-of-the-art computer simulations of short DNA sequences are preformed to provide an atomistic description of the stretching of the DNA double helix. These calculations show that for extensions larger that approximately 25% the DNA undergoes a structural transformation and a few base pairs are lost from both the terminal and central part of the helix. This locally melted DNA duplex is stable and can be extended up to approximately 50-60% of the equilibrium length at a constant force. It is concluded that melting under tension cannot be modeled as a simple two-state process. Finally, the important role of the cantilever stiffness in determining the shape of the force-extension curve and the most probable rupture force is discussed.
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