Evidence map›Paper›PMID 16356240›Full record

ReviewCritical care (London, England)2005

Functional hemodynamic monitoring.

Michael R Pinsky, Didier Payen

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Critical care (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 94 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02070276 nacompletednot on this mapstarted 2014, after this paper: background citation

Can Non Invasive Methods for Fluid Responsive Assessment Optimize Preventive Volemic Repletion in Order to Prevent Significant Hypotension After Spinal Anesthesia? A Randomized Trial

TypeinterventionalSponsorEnte Ospedaliero Cantonale, BellinzonaRan2014 to 2019Enrolled429ConditionsHypotension and Shock, Excessive Amount of Blood / Fluid InfusionArmsTrans-thoracic echocardiography, Passive Leg Raising Test
NCT04664699 nacompletednot on this mapstarted 2019, after this paper: background citation

Comparison of Standard Monitoring and Plethysmographic Variability Index-Guided Fluid Therapy In Severe Traumatic Brain Injury Patients Scheduled for Emergency Craniotomies: A Randomised Control Trial

TypeinterventionalSponsorUniversiti Sains MalaysiaRan2019 to 2020Enrolled64ConditionsSevere Traumatic Brain InjuryArmsPlethymographic Variability Index, Standard Monitoring
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Trial
  7. Article
  8. Personalised fluid therapy in septic shock.Annals of intensive care · 2026
    Review
  9. Article
  10. Review
  11. Assessing volume status in heart failure: The role of renal duplex ultrasound in evaluating cardiorenal morbidity and heart failure mortality.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael R PinskyDepartment of Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. pinskymr@ccm.upmc.edu
Didier Payen

Funding

Multidisciplinary Training in Critical Care Outcomes ResearchT32HL007820 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Timothy D Girard, Jeremy M Kahn · 1996 to 2026
$6.4M
Heart-Lung Interactions &Cardiovascular InsufficiencyK24HL067181 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PINSKY, MICHAEL R · 2002 to 2011
$1.4M
NHLBI NIH HHS HL07820NHLBI NIH HHS HL67181NHLBI NIH HHS K24 HL067181NHLBI NIH HHS T32 HL007820
6 · The paper itself

Abstract

Hemodynamic monitoring is a central component of intensive care. Patterns of hemodynamic variables often suggest cardiogenic, hypovolemic, obstructive, or distributive (septic) etiologies to cardiovascular insufficiency, thus defining the specific treatments required. Monitoring increases in invasiveness, as required, as the risk for cardiovascular instability-induced morbidity increases because of the need to define more accurately the diagnosis and monitor the response to therapy. Monitoring is also context specific: requirements during cardiac surgery will be different from those in the intensive care unit or emergency department. Solitary hemodynamic values are useful as threshold monitors (e.g. hypotension is always pathological, central venous pressure is only elevated in disease). Some hemodynamic values can only be interpreted relative to metabolic demand, whereas others have multiple meanings. Functional hemodynamic monitoring implies a therapeutic application, independent of diagnosis such as a therapeutic trial of fluid challenge to assess preload responsiveness. Newer methods for assessing preload responsiveness include monitoring changes in central venous pressure during spontaneous inspiration, and variations in arterial pulse pressure, systolic pressure, and aortic flow variation in response to vena caval collapse during positive pressure ventilation or passive leg raising. Defining preload responsiveness using these functional measures, coupled to treatment protocols, can improve outcome from critical illness. Potentially, as these and newer, less invasive hemodynamic measures are validated, they could be incorporated into such protocolized care in a cost-effective manner.

Indexed as

HemodynamicsBlood Pressure DeterminationBlood Volume DeterminationCatheterization, Central VenousCatheterization, Swan-GanzCritical CareEvidence-Based MedicineHumansMonitoring, PhysiologicPoint-of-Care SystemsPositive-Pressure RespirationReference ValuesStroke Volume

Identifiers

PMID16356240
PMCPMC1414021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.