ArticleCritical care (London, England)2005
Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study.
Article in Critical care (London, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Recommendations for the use of albumin and immunoglobulins.Blood transfusion = Trasfusione del sangue · 2009Guideline
- Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials.Critical care (London, England) · 2008Pooled it
- Albumin in Burn Shock Resuscitation: A Meta-Analysis of Controlled Clinical Studies.Journal of burn care & research : official publication of the American Burn AssociationPooled it
- Commentary: Revisiting the Effectiveness of Albumin Administration in Critical Care: Insights for Extracorporeal Membrane Oxygenation Patients with Cardiogenic Shock.Journal of chest surgery · 2023Article
- Machine learning-based prediction of low-value care for hospitalized patients.Intelligence-based medicine · 2023Article
- Association between serum albumin and mortality in Japan older people with dysphagia.Scientific reports · 2022Article
- The Risk Factors for Perioperative Serum Albumin Variation in Pediatric Patients Undergoing Major Gastroenterology Surgery.Frontiers in surgery · 2020Article
- The Influence of Albumin Level in Critically Ill Children to Length of Stay and Mortality in Paediatric Intensive Care Unit.Open access Macedonian journal of medical sciences · 2019Article
- Overview of Albumin and Its Purification Methods.Advanced pharmaceutical bulletin · 2016Review
- Mixed colloids and acute kidney injury: a case of selection bias?Critical care (London, England) · 2015Article
- Albumin administration is associated with acute kidney injury in cardiac surgery: a propensity score analysis.Critical care (London, England) · 2014Article
- [Albumin in severe sepsis or septic shock: should it be administered?].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2014Article
- Albumin administration in the acutely ill: what is new and where next?Critical care (London, England) · 2014Review
- The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study.Critical care (London, England) · 2013Observational
- A Microtus fortis protein, serum albumin, is a novel inhibitor of Schistosoma japonicum schistosomula.Memorias do Instituto Oswaldo Cruz · 2013Article
- The immunomodulatory effects of albumin in vitro and in vivo.Advances in pharmacological sciences · 2011Article
- Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry.Infection · 2009Article
- Human serum albumin improves arterial dysfunction during early resuscitation in mouse endotoxic model via reduced oxidative and nitrosative stresses.The American journal of pathology · 2007Article
- Resuscitation using albumin in critically ill patients: research in patients at high risk of complications is now needed.BMJ (Clinical research ed.) · 2006Article
- Year in review 2005: Critical Care - resource management.Critical care (London, England) · 2006Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAlbumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome.
methodsIn a cohort, multicenter, observational study, all patients admitted to one of the participating ICUs between 1 May and 15 May 2002 were followed up until death, hospital discharge, or for 60 days. Patients were classified according to whether or not they received albumin at any time during their ICU stay.
resultsOf 3,147 admitted patients, 354 (11.2%) received albumin and 2,793 (88.8%) did not. Patients who received albumin were more likely to have cancer or liver cirrhosis, to be surgical admissions, and to have sepsis. They had a longer length of ICU stay and a higher mortality rate, but were also more severely ill, as manifested by higher simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores than the other patients. A Cox proportional hazard model indicated that albumin administration was significantly associated with decreased 30-day survival. Moreover, in 339 pairs matched according to a propensity score, ICU and hospital mortality rates were higher in the patients who had received albumin than in those who had not (34.8 versus 20.9% and 41.3 versus 27.7%, respectively, both p < 0.001).
conclusionAlbumin administration was associated with decreased survival in this population of acutely ill patients. Further prospective randomized controlled trials are needed to examine the effects of albumin administration in sub-groups of acutely ill patients.
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