ArticlePLoS genetics2005
Clines, clusters, and the effect of study design on the inference of human population structure.
Article in PLoS genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
234 citing papers in PubMed.
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- Reflections on the Human Genome Diversity Project: a conversation with Marcus W. Feldman, Henry T. Greely, and Mary-Claire King.Genetics · 2026Article
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- Using mathematical constraints to explain narrow ranges for allele-sharing dissimilarities.Theoretical population biology · 2025Article
- The History of the Panmictic Population Concept and Its Legacy in Contemporary Population Genetics.Annals of human genetics · 2025Article
- Revealing the range of equally likely estimates in the admixture model.G3 (Bethesda, Md.) · 2025Article
- The risk of biological race.History and philosophy of the life sciences · 2025Article
- Genetic Ancestry and 21-Gene Oncotype DX Breast Cancer Recurrence Scores.Annals of surgical oncology · 2025Article
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- Genetic ancestry and population structure in the All of Us Research Program cohort.Nature communications · 2025Article
- A Pipeline and Recommendations for Population and Individual Diagnostic SNP Selection in Non-Model Species.Molecular ecology resources · 2025Article
- Population Genetics Meets Ecology: A Guide to Individual-Based Simulations in Continuous Landscapes.Ecology and evolution · 2025Article
- Impediments to countering racist pseudoscience.Evolutionary human sciences · 2025Article
- Genes, culture, and scientific racism.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Analysis of Gyimes Csango population samples on a high-resolution genome-wide basis.BMC genomics · 2024Article
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- Cross-cultural perception of strength, attractiveness, aggressiveness and helpfulness of Maasai male faces calibrated to handgrip strength.Scientific reports · 2024Article
174 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Previously, we observed that without using prior information about individual sampling locations, a clustering algorithm applied to multilocus genotypes from worldwide human populations produced genetic clusters largely coincident with major geographic regions. It has been argued, however, that the degree of clustering is diminished by use of samples with greater uniformity in geographic distribution, and that the clusters we identified were a consequence of uneven sampling along genetic clines. Expanding our earlier dataset from 377 to 993 markers, we systematically examine the influence of several study design variables--sample size, number of loci, number of clusters, assumptions about correlations in allele frequencies across populations, and the geographic dispersion of the sample--on the "clusteredness" of individuals. With all other variables held constant, geographic dispersion is seen to have comparatively little effect on the degree of clustering. Examination of the relationship between genetic and geographic distance supports a view in which the clusters arise not as an artifact of the sampling scheme, but from small discontinuous jumps in genetic distance for most population pairs on opposite sides of geographic barriers, in comparison with genetic distance for pairs on the same side. Thus, analysis of the 993-locus dataset corroborates our earlier results: if enough markers are used with a sufficiently large worldwide sample, individuals can be partitioned into genetic clusters that match major geographic subdivisions of the globe, with some individuals from intermediate geographic locations having mixed membership in the clusters that correspond to neighboring regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.