ArticleGenes and immunity2006
Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Complement's involvement in allergic Th2 immunity: a cross-barrier perspective.The Journal of clinical investigation · 2025Review
- Complement C1q essential for aeroallergen sensitization via CSF1RThe Journal of allergy and clinical immunology · 2023Article
- C3a is required for ILC2 function in allergic airway inflammation.Mucosal immunology · 2018Article
- Mechanism of TThe Journal of allergy and clinical immunology · 2017Article
- Analysis of ComplementFrontiers in immunology · 2017Article
- Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality.Future virology · 2015Article
- The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.American journal of respiratory and critical care medicine · 2012Article
- The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma.Current allergy and asthma reports · 2011Review
- Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma.Nature immunology · 2010Article
- The landscape of human genes involved in the immune response to parasitic worms.BMC evolutionary biology · 2010Article
- A complex role for complement in allergic asthma.Expert review of clinical immunology · 2010Review
- Gains in power for exhaustive analyses of haplotypes using variable-sized sliding window strategy: a comparison of association-mapping strategies.European journal of human genetics : EJHG · 2009Article
- Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro.Immunology · 2008Article
- Association study of the C3 gene with adult and childhood asthma.Journal of human genetics · 2008Article
- Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations.Translational research : the journal of laboratory and clinical medicine · 2007Article
- Complement activation pathways: a bridge between innate and adaptive immune responses in asthma.Proceedings of the American Thoracic Society · 2007Review
Corrections and comments
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Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
Proinflammatory and immunoregulatory products from C3 play a major role in phagocytosis, respiratory burst, and airways inflammation. C3 is critical in adaptive immunity; studies in mice deficient in C3 demonstrate that features of asthma are significantly attenuated in the absence of C3. To test the hypothesis that the C3 gene on chromosome 19p13.3-p13.2 contains variants associated with asthma and related phenotypes, we genotyped 25 single nucleotide polymorphism (SNP) markers distributed at intervals of approximately 1.9 kb within the C3 gene in 852 African Caribbean subjects from 125 nuclear and extended pedigrees. We used the multiallelic test in the family-based association test program to examine sliding windows comprised of 2-6 SNPs. A five-SNP window between markers rs10402876 and rs366510 provided strongest evidence for linkage in the presence of linkage disequilibrium for asthma, high log[total IgE], and high log[IL-13]/[log[IFN-gamma] in terms of global P-values (P = 0.00027, 0.00013, and 0.003, respectively). A three-SNP haplotype GGC for the first three of these markers showed best overall significance for the three phenotypes (P = 0.003, 0.007, 0.018, respectively) considering haplotype-specific tests. Taken together, these results implicate the C3 gene as a priority candidate controlling risk for asthma and allergic disease in this population of African descent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.