ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Spinal cord-transected mice learn to step in response to quipazine treatment and robotic training.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- A systematic review of exercise training to promote locomotor recovery in animal models of spinal cord injury.Journal of neurotrauma · 2012Pooled it
- A systematic review of the effects of pharmacological agents on walking function in people with spinal cord injury.Journal of neurotrauma · 2012Pooled it
- Trial
- Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.Journal of neurotrauma · 2014Trial
- Methods to quantify pharmacologically induced alterations in motor function in human incomplete SCI.Journal of visualized experiments : JoVE · 2011Trial
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- An infrastructure for qualified data sharing and team science in late-stage translational spinal cord injury research.Experimental neurology · 2025Review
- A fresh look at propriospinal interneurons plasticity and intraspinal circuits remodeling after spinal cord injury.IBRO neuroscience reports · 2023Article
- Neurotransmitter phenotype switching by spinal excitatory interneurons regulates locomotor recovery after spinal cord injury.Nature neuroscience · 2022Article
- Review
- Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury.Frontiers in cellular neuroscience · 2022Article
- Redundancy and multifunctionality among spinal locomotor networks.Journal of neurophysiology · 2020Article
- Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs.Brain sciences · 2020Article
- From cortex to cord: motor circuit plasticity after spinal cord injury.Neural regeneration research · 2019Review
- Rehabilitation following spinal cord injury: how animal models can help our understanding of exercise-induced neuroplasticity.Neural regeneration research · 2019Review
- Adenosine AMolecular neurobiology · 2019Article
- Propriospinal Neurons: Essential Elements of Locomotor Control in the Intact and Possibly the Injured Spinal Cord.Frontiers in cellular neuroscience · 2019Review
- Novel Activity Detection Algorithm to Characterize Spontaneous Stepping During Multimodal Spinal Neuromodulation After Mid-Thoracic Spinal Cord Injury in Rats.Frontiers in systems neuroscience · 2019Article
- Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury.Journal of neurophysiology · 2018Review
- And yet it moves: Recovery of volitional control after spinal cord injury.Progress in neurobiology · 2018Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
In the present study, concurrent treatment with robotic step training and a serotonin agonist, quipazine, generated significant recovery of locomotor function in complete spinal cord-transected mice (T7-T9) that otherwise could not step. The extent of recovery achieved when these treatments were combined exceeded that obtained when either treatment was applied independently. We quantitatively analyzed the stepping characteristics of spinal mice after alternatively administering no training, manual training, robotic training, quipazine treatment, or a combination of robotic training with quipazine treatment, to examine the mechanisms by which training and quipazine treatment promote functional recovery. Using fast Fourier transform and principal components analysis, significant improvements in the step rhythm, step shape consistency, and number of weight-bearing steps were observed in robotically trained compared with manually trained or nontrained mice. In contrast, manual training had no effect on stepping performance, yielding no improvement compared with nontrained mice. Daily bolus quipazine treatment acutely improved the step shape consistency and number of steps executed by both robotically trained and nontrained mice, but these improvements did not persist after quipazine was withdrawn. At the dosage used (0.5 mg/kg body weight), quipazine appeared to facilitate, rather than directly generate, stepping, by enabling the spinal cord neural circuitry to process specific patterns of sensory information associated with weight-bearing stepping. Via this mechanism, quipazine treatment enhanced kinematically appropriate robotic training. When administered intermittently during an extended period of robotic training, quipazine revealed training-induced stepping improvements that were masked in the absence of the pharmacological treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.