ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Distinct mechanisms for neurotrophin-3-induced acute and long-term synaptic potentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Neurotrophin-3 Rescues Striatal Synaptic Plasticity in Model of Neurodegeneration by PLC Signaling Activation.CNS & neurological disorders drug targets · 2024Article
- Akt Interacts with Usutu Virus Polymerase, and Its Activity Modulates Viral Replication.Pathogens (Basel, Switzerland) · 2021Article
- Impact of High-Fat Diet and Early Stress on Depressive-Like Behavior and Hippocampal Plasticity in Adult Male Rats.Molecular neurobiology · 2018Article
- Neurotrophin-3 restores synaptic plasticity in the striatum of a mouse model of Huntington's disease.CNS neuroscience & therapeutics · 2018Article
- Effects of skilled reach training with affected forelimb and treadmill exercise on the expression of neurotrophic factor following ischemia-induced brain injury in rats.Journal of physical therapy science · 2017Article
- Purinergic neuron-glia interactions in sensory systems.Pflugers Archiv : European journal of physiology · 2014Review
- Skilled reach training influences brain recovery following intracerebral hemorrhage in rats.Journal of physical therapy science · 2014Article
- Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure.Journal of neurodevelopmental disorders · 2013Article
- Effects of neurotrophin-3 on the differentiation of neural stem cells into neurons and oligodendrocytes.Neural regeneration research · 2012Article
- Presynaptic protein synthesis required for NT-3-induced long-term synaptic modulation.Molecular brain · 2011Article
- Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses.The Journal of cell biology · 2009Article
- Neurotrophin 3 induces structural and functional modification of synapses through distinct molecular mechanisms.The Journal of cell biology · 2006Article
- Pathophysiological mechanisms for actions of the neurotrophins.Brain pathology (Zurich, Switzerland) · 2006Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although neurotrophins elicit both acute and long-term effects, it is unclear whether the two modes of action are mediated by the same or different mechanisms. Using neuromuscular junction (NMJ) as a model system, we identified three characteristic features required for long-term, but not acute, forms of synaptic modulation by neurotrophin-3 (NT-3): endocytosis of NT-3-receptor complex, activation of the PI3 kinase substrate Akt, and new protein synthesis. Long-term effects were eliminated when NT-3 was conjugated to a bead that was too large to be endocytosed or when dominant-negative dynamin was expressed in presynaptic neurons. Presynaptic inhibition of Akt also selectively prevented NT-3-mediated long-term effects. Blockade of protein translation by the mammalian target of rapamycin inhibitor rapamycin prevented the long-term structural and functional changes at the NMJ, without affecting the acute potentiation of synaptic transmission by NT-3. These results reveal fundamental differences between acute and long-term modulation by neurotrophins.
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