ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 66 citations in OpenAlex.
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- Synaptic Integration of Subquantal Neurotransmission by Colocalized G Protein-Coupled Receptors in Presynaptic Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons.eLife · 2021Article
- δ subunit-containing GABAThe Journal of physiology · 2020Article
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- Chronic stress dampens excitatory synaptic gain in the paraventricular nucleus of the hypothalamus.The Journal of physiology · 2018Article
- Transcellular Nanoalignment of Synaptic Function.Neuron · 2017Review
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- Endocannabinoids control vesicle release mode at midbrain periaqueductal grey inhibitory synapses.The Journal of physiology · 2017Article
- Train stimulation of parallel fibre to Purkinje cell inputs reveals two populations of synaptic responses with different receptor signatures.The Journal of physiology · 2016Article
- Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing.Cerebellum (London, England) · 2016Article
- The ubiquitous nature of multivesicular release.Trends in neurosciences · 2015Review
- Developmental tightening of cerebellar cortical synaptic influx-release coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The properties of a synapse are crucially dependent on whether an action potential can trigger the release of multiple vesicles at an individual release site [multivesicular release (MVR)] and whether fusion of a single vesicle leads to receptor saturation. MVR and receptor saturation both occur at some high p synapses, but it is not known whether they also occur at low p synapses. Here we examine this issue at the low p synapse between parallel fibers and Purkinje cells using the low-affinity antagonist DGG (gamma-D-glutamylglycine) to relieve AMPA receptor saturation. We find that the presence of MVR and receptor saturation at this synapse alters the calcium dependence of synaptic transmission and reduces the extent of facilitation. These findings establish that MVR and postsynaptic receptor saturation can influence transmission even at synapses with a low initial probability of release and suggest that these properties may be common at synapses in the mammalian brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.