ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
A C-terminal domain directs Kv3.3 channels to dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Proper localization of the SCA13-linked KNeurobiology of disease · 2026Article
- Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes.eLife · 2023Article
- Modeling of sustained spontaneous network oscillations of a sexually dimorphic brainstem nucleus: the role of potassium equilibrium potential.Journal of computational neuroscience · 2021Article
- Differences in Sodium Channel Densities in the Apical Dendrites of Pyramidal Cells of the Electrosensory Lateral Line Lobe.Frontiers in neural circuits · 2019Article
- Balanced ionotropic receptor dynamics support signal estimation via voltage-dependent membrane noise.Journal of neurophysiology · 2016Article
- The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation.BMC genomics · 2015Article
- Article
- Function and mechanism of axonal targeting of voltage-sensitive potassium channels.Progress in neurobiology · 2011Review
- Inhibition of SK and M channel-mediated currents by 5-HT enables parallel processing by bursts and isolated spikes.Journal of neurophysiology · 2011Article
- Article
- The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Polarized targeting of ion channels in neurons.Pflugers Archiv : European journal of physiology · 2007Review
- Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.Molecular and cellular neurosciences · 2007Article
- Ionic and neuromodulatory regulation of burst discharge controls frequency tuning.Journal of physiology, ParisReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyramidal neurons of the electrosensory lateral line lobe (ELL) of Apteronotus leptorhynchus express Kv3-type voltage-gated potassium channels that give rise to high-threshold currents at the somatic and dendritic levels. Two members of the Kv3 channel family, AptKv3.1 and AptKv3.3, are coexpressed in these neurons. AptKv3.3 channels are expressed at uniformly high levels in each of four ELL segments, whereas AptKv3.1 channels appear to be expressed in a graded manner with higher levels of expression in segments that process high-frequency electrosensory signals. Immunohistochemical and recombinant channel expression studies show a differential distribution of these two channels in the dendrites of ELL pyramidal neurons. AptKv3.1 is concentrated in somas and proximal dendrites, whereas AptKv3.3 is distributed throughout the full extent of the large dendritic tree. Recombinant channel expression of AptKv3 channels through in vivo viral injections allowed directed retargeting of AptKv3 subtypes over the somadendritic axis, revealing that the sequence responsible for targeting channels to distal dendrites lies within the C-terminal domain of the AptKv3.3 protein. The targeting domain includes a consensus sequence predicted to bind to a PDZ (postsynaptic density-95/Discs large/zona occludens-1)-type protein-protein interaction motif. These findings reveal that different functional roles for Kv3 potassium channels at the somatic and dendritic level of a sensory neuron are attained through specific targeting that selectively distributes Kv3.3 channels to the dendritic compartment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.